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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended
	Sep. 30, 2022	Dec. 31, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaboration and royalty revenue
Revenue			$ 698,801	$ 538,593	$ 380,766
Collaboration and grant revenue
Collaboration and royalty revenue
Revenue			50,052	55,046	42,579
Royalty revenue
Collaboration and royalty revenue
Revenue			113,521	54,643	4,786
SMA License Agreement | Collaboration and grant revenue
Collaboration and royalty revenue
Revenue			50,100	55,000	42,600
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue			113,500	$ 54,600	$ 4,800
SMA License Agreement | Sales Milestones
Collaboration and royalty revenue
Net sales milestone threshold achieved	$ 750,000		$ 500,000
SMA License Agreement | Sales Milestones | Prepaids and other current assets
Collaboration and royalty revenue
Milestone payments due	$ 50,000	$ 25,000

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