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Fair value of financial instruments and investments - Hierarchy (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	$ 22,610	$ 376,685
Contingent consideration payable	164,000	239,900
Transfers from Level 1 to Level 2	0	0
Transfers from Level 2 to Level 1	0	0
Recurring basis
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	22,610	376,685
Marketable securities - equity investments	108,261	206,973
ClearPoint Equity Investments	10,965	14,525
ClearPoint convertible debt security	15,231	20,971
Recurring basis | Quoted prices in active markets for identical assets (Level 1)
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - equity investments	108,261	206,973
ClearPoint Equity Investments	10,965	14,525
Recurring basis | Significant other observable inputs (Level 2)
Financial assets and liabilities measured at fair value on recurring basis
Marketable securities - available for sale	22,610	376,685
ClearPoint convertible debt security	15,231	20,971
Recurring basis | Development and Regulatory Milestones
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	82,500	139,300
Recurring basis | Development and Regulatory Milestones | Significant unobservable inputs (Level 3)
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	82,500	139,300
Recurring basis | Net Sales Milestones and Royalties
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	81,500	100,600
Recurring basis | Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3)
Financial assets and liabilities measured at fair value on recurring basis
Contingent consideration payable	$ 81,500	$ 100,600

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Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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