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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Jun. 08, 2022
Dec. 31, 2022
Dec. 31, 2020
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Apr. 30, 2022
Jun. 30, 2021
May 31, 2021
Jan. 31, 2020
Stock option plan                    
Share-based compensation expense       $ 110,333 $ 103,513 $ 70,325        
Unrecognized compensation cost   $ 176,100   $ 176,100            
Weighted average remaining service period for recognition of unrecognized compensation cost       2 years 2 months 8 days            
Stock option                    
Stock option plan                    
Granted (in shares)       1,685,435 2,487,234 2,777,975        
Forfeited (in shares)       458,737 742,458 889,785        
Expected dividend yield (as a percent)       0.00% 0.00% 0.00%        
Weighted average grant date fair value (in dollars per share)       $ 23.54 $ 43.05 $ 36.94        
Stock option | Maximum                    
Stock option plan                    
Vesting period       4 years            
Employee Stock Purchase Plan                    
Stock option plan                    
Number of shares authorized (in shares)               2,000,000 1,000,000  
Award requisite service period       6 months            
Share-based compensation expense       $ 2,400            
Employee Stock Purchase Plan | Minimum                    
Stock option plan                    
Purchase price of common stock, percent       85.00%            
Employee stock purchase plan, voting percentage limit       5.00%            
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan                    
Stock option plan                    
Number of shares available for issuance   0   0            
Amended 2013 LTIP                    
Stock option plan                    
Number of additional shares authorized (in shares) 8,475,000                  
Amended 2013 LTIP | Maximum                    
Stock option plan                    
Number of shares authorized (in shares) 16,724,212                  
2013 Long Term Incentive Plan                    
Stock option plan                    
Number of shares available for issuance   9,126,463   9,126,463            
2020 Inducement Stock Incentive Plan                    
Stock option plan                    
Number of shares available for issuance   1,820,565   1,820,565            
Number of additional shares authorized (in shares)     1,000,000              
2020 Inducement Stock Incentive Plan | Maximum                    
Stock option plan                    
Number of shares authorized (in shares)                   1,000,000
2020 Inducement Stock Incentive Plan | Common stock | Maximum                    
Stock option plan                    
Number of shares authorized (in shares)             1,300,000      
Number of additional shares authorized (in shares)   1,700,000                
2020 Inducement Stock Incentive Plan | Stock option                    
Stock option plan                    
Granted (in shares)         104,385          
Forfeited (in shares)         237,700          
Stockholder's specified ownership percentage   10.00%   10.00%            
Expiration period       10 years            
Granted (in dollars per share)         $ 42.02          
2020 Inducement Stock Incentive Plan | Stock option | Minimum                    
Stock option plan                    
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date   100.00%   100.00%            
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date   110.00%   110.00%            
2020 Inducement Stock Incentive Plan | Restricted stock units                    
Stock option plan                    
Granted (in shares)         43,800          
Forfeited (in shares)         26,336