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Revenue recognition - Net Product Sales (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($) segment country Distributor	Dec. 31, 2021 USD ($) country Distributor	Dec. 31, 2020 USD ($) Distributor country
Net product sales
Number of operating segments | segment	1
Revenue	$ 698,801	$ 538,593	$ 380,766
Contract with customer, liability	1,400	0
Contract with customer, assets	0	0
Performance obligations satisfied in period		4,000
United States
Net product sales
Revenue	498,567	297,005
Non-US
Net product sales
Revenue	$ 200,234	$ 241,588
Net product revenue | Geographic concentration risk
Net product sales
Number of countries exceeding 10% of net product sales | country	2	1	1
Percentage of net product sales threshold	10.00%	10.00%	10.00%
Net product revenue | Customer concentration risk
Net product sales
Number of distributors | Distributor	2	2	2
Percentage of net product sales threshold	10.00%	10.00%	10.00%
Net product revenue
Net product sales
Revenue	$ 535,228	$ 428,904	$ 333,401
Net product revenue | Non-US
Net product sales
Revenue	316,900	241,600	194,400
Net product revenue | Net product revenue | Geographic concentration risk | United States
Net product sales
Revenue	218,300
Net product revenue | Net product revenue | Geographic concentration risk | Russia
Net product sales
Revenue	59,700
Emflaza | United States
Net product sales
Revenue	218,300	187,300	139,000
Translarna | Non-US
Net product sales
Revenue	$ 288,600	$ 236,000	$ 191,900

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