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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	1 Months Ended		12 Months Ended
	Sep. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($) payment	Dec. 31, 2020 USD ($) payment	Aug. 31, 2021 USD ($)	Mar. 31, 2021 USD ($)	Oct. 31, 2020 USD ($)	Aug. 31, 2020 USD ($)	Nov. 30, 2011 USD ($)
Collaboration and royalty revenue
Remaining potential milestones that can be achieved			$ 250,000
Revenue			698,801	$ 538,593	$ 380,766
Collaboration revenue
Collaboration and royalty revenue
Revenue			50,052	55,046	42,579
Royalty revenue
Collaboration and royalty revenue
Revenue			113,521	54,643	4,786
SMA License Agreement | Collaboration revenue
Collaboration and royalty revenue
Revenue			50,100	55,000	42,600
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue			113,500	$ 54,600	$ 4,800
Research and Development and Sales Milestones | Collaboration revenue
Collaboration and royalty revenue
Number of milestone payments. | payment				3	3
Research And Development Event Milestones | SMA License Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved			0
Milestone payments received						$ 10,000	$ 20,000	$ 7,500
Research And Development Event Milestones, Period Payment 1 | SMA License Agreement
Collaboration and royalty revenue
Milestone payments received									$ 20,000
Research And Development Event Milestones, Period Payment 2 | SMA License Agreement
Collaboration and royalty revenue
Milestone payments received									$ 15,000
Sales Milestones | SMA License Agreement
Collaboration and royalty revenue
Remaining potential milestones that can be achieved			250,000
Net sales milestone threshold achieved	$ 750,000		$ 500,000
Sales Milestones | SMA License Agreement | Prepaids and other current assets
Collaboration and royalty revenue
Milestone payments due	$ 50,000	$ 25,000
Maximum | Research And Development Event Milestones | SMA License Agreement | Roche
Collaboration and royalty revenue
Remaining potential milestones that can be achieved										$ 135,000
Maximum | Sales Milestones | SMA License Agreement | Roche
Collaboration and royalty revenue
Remaining potential milestones that can be achieved										$ 325,000

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