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ACCESSION NUMBER:		0001104659-23-030113
CONFORMED SUBMISSION TYPE:	10-K/A
PUBLIC DOCUMENT COUNT:		14
CONFORMED PERIOD OF REPORT:	20221231
FILED AS OF DATE:		20230308
DATE AS OF CHANGE:		20230308

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PTC THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001070081
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043416587
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		10-K/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35969
		FILM NUMBER:		23716321

	BUSINESS ADDRESS:	
		STREET 1:		100 CORPORATE COURT
		CITY:			SOUTH PLAINFIELD
		STATE:			NJ
		ZIP:			07080-2449
		BUSINESS PHONE:		9082227000

	MAIL ADDRESS:	
		STREET 1:		100 CORPORATE COURT
		CITY:			SOUTH PLAINFIELD
		STATE:			NJ
		ZIP:			07080-2449

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PTC THERAPEUTICS INC
		DATE OF NAME CHANGE:	19980909
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>UNITED STATES</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>SECURITIES AND EXCHANGE COMMISSION</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Washington, D.C. 20549</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>FORM&#160;<span id="xdx_90F_edei--DocumentType_c20220101__20221231_zN3na79koH72"><ix:nonNumeric contextRef="From2022-01-01to2022-12-31" name="dei:DocumentType">10-K/A</ix:nonNumeric></span></b></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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    <td style="font-size: 10pt"><span style="font-size: 10pt"><b>ANNUAL REPORT PURSUANT TO SECTION&#160;13 OR 15(d)&#160;OF THE SECURITIES EXCHANGE ACT OF&#160;1934</b></span></td>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">or</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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    <td style="font-size: 10pt"><span style="font-size: 10pt"><b>TRANSITION REPORT PURSUANT TO SECTION&#160;13 OR 15(d)&#160;OF THE SECURITIES EXCHANGE ACT OF 1934</b></span></td>
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact name of registrant as specified in its charter)</p>

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<p style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Securities registered pursuant to Section&#160;12(b)&#160;of the Act:</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Securities registered pursuant to Section&#160;12(g)&#160;of the Act: <b>None</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="border-top: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted and posted pursuant to Rule&#160;405 of Regulation&#160;S-T (&#167;232.405 of this chapter) during the preceding 12&#160;months (or for such shorter period that the registrant was required to submit such files). <span id="xdx_90C_edei--EntityInteractiveDataCurrent_c20220101__20221231_zpAL7ciTWpw1"><ix:nonNumeric contextRef="From2022-01-01to2022-12-31" name="dei:EntityInteractiveDataCurrent">Yes</ix:nonNumeric></span>&#160;<span style="font-family: Times New Roman, Times, Serif"><span style="font-family: Wingdings">x</span></span>&#160;&#160;&#160;&#160;No&#160;<span style="font-family: Times New Roman, Times, Serif"><span style="font-family: Wingdings">&#168;</span></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company,&#8221; and &#8220;emerging growth company&#8221; in Rule&#160;12b-2 of the Exchange Act.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;13(a)&#160;of the Exchange Act. <span style="font-family: Times New Roman, Times, Serif"><span style="font-family: Wingdings">&#168;</span></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><span style="font-size: 10pt">Indicate by check mark whether the registrant has filed a report on and attestation to its management&#8217;s assessment of the effectiveness of its internal control over financial reporting under Section&#160;404(b)&#160;of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report.&#160;</span><span style="font-family: Times New Roman, Times, Serif"><span style="font-family: Wingdings"><span id="xdx_90D_edei--IcfrAuditorAttestationFlag_c20220101__20221231_zGqLqEA1Isz1"><ix:nonNumeric contextRef="From2022-01-01to2022-12-31" format="ixt:booleantrue" name="dei:IcfrAuditorAttestationFlag">x</ix:nonNumeric></span></span></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Indicate by check mark whether the registrant is a shell company (as defined in Rule&#160;12b-2 of the Exchange Act). Yes&#160;<span style="font-family: Wingdings">&#168;</span>&#160;&#160;&#160;&#160;<span id="xdx_908_edei--EntityShellCompany_dxL_c20220101__20221231_zHd0X2Ky8QOi" title="::XDX::false"><span style="-sec-ix-hidden: xdx2ixbrl0038">No</span></span>&#160;<span style="font-family: Times New Roman, Times, Serif"><span style="font-family: Wingdings">x</span></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If securities are registered pursuant to Section&#160;12(b)&#160;of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. <span style="font-family: Wingdings">&#168;</span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant&#8217;s executive officers during the relevant recovery period pursuant to &#167;&#8201;240.10D-1(b). <span style="font-family: Wingdings">&#168;</span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The aggregate market value of the Common Stock held by non-affiliates of the registrant, based upon the last sale price of the Common Stock reported on the Nasdaq Global Select Market on June&#160;30, 2022, the last business day of the registrant&#8217;s most recently completed second fiscal quarter, was $<span id="xdx_90E_edei--EntityPublicFloat_iI_pdp0_c20220630_zl5I7zMkOHa9"><ix:nonFraction name="dei:EntityPublicFloat" contextRef="AsOf2022-06-30" format="ixt:numdotdecimal" decimals="0" scale="0" unitRef="USD">2,129,532,394</ix:nonFraction></span>. For purposes of this calculation, shares of Common Stock held by directors and officers have been treated as shares held by affiliates.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">As of February&#160;16, 2023, the registrant had <span id="xdx_90B_edei--EntityCommonStockSharesOutstanding_iI_pdp0_c20230216_z7pydlN7b101"><ix:nonFraction name="dei:EntityCommonStockSharesOutstanding" contextRef="AsOf2023-02-16" format="ixt:numdotdecimal" decimals="INF" scale="0" unitRef="Shares">73,815,144</ix:nonFraction></span> shares of Common Stock, $0.001 par value per share, outstanding.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<div id="xdx_98A_edei--DocumentsIncorporatedByReferenceTextBlock_c20220101__20221231_z2nFbbcM86m6"><ix:nonNumeric contextRef="From2022-01-01to2022-12-31" escape="true" name="dei:DocumentsIncorporatedByReferenceTextBlock">

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="background-color: white"><b>DOCUMENTS INCORPORATED BY REFERENCE</b></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><span style="background-color: white">Part&#160;III of this Annual Report incorporates by reference information from the definitive Proxy Statement for the registrant&#8217;s 2023 Annual Meeting of Shareholders which is expected to be filed with the Securities and Exchange Commission not later than 120&#160;days after the registrant&#8217;s fiscal&#160;year ended December&#160;31, 2022.</span></p>

</ix:nonNumeric></div>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

<!-- Field: Rule-Page --><div style="margin-top: 0; margin-bottom: 0; width: 100%"><div style="border-top: Black 1pt solid; border-bottom: Black 2pt solid; font-size: 1pt">&#160;</div></div><!-- Field: /Rule-Page -->

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

<!-- Field: Page; Sequence: 1 -->
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>EXPLANATORY NOTE</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><span id="xdx_908_edei--AmendmentDescription_c20220101__20221231_zyO0KHlD7td4"><ix:nonNumeric contextRef="From2022-01-01to2022-12-31" name="dei:AmendmentDescription">This Amendment No.&#160;1 on Form&#160;10-K/A
(&#8220;Amendment No.&#160;1&#8221;) to the Annual Report on Form&#160;10-K of PTC Therapeutics,&#160;Inc. (the &#8220;Company&#8221;)
for the year ended December&#160;31, 2022, originally filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on February&#160;21,
2023 (the &#8220;Original Filing&#8221;), is being filed solely for the purpose of amending Item 15, Exhibits and Financial Statement
Schedules, of Part&#160;IV, to add reference to new Exhibits 10.57, 10.58 and 10.59. References in the exhibit index to these exhibits,
which are incorporated by reference to prior filings by the Company with the SEC, were inadvertently omitted from the Original Filing
due to an administrative error.</ix:nonNumeric></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">In addition, as required by Rule&#160;12b-15 under
the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), new certifications by our principal executive officer
and principal financial officer pursuant to Rules&#160;13a-14(a)&#160;and 15d-14(a)&#160;of the Exchange Act are filed as exhibits to
this Amendment No.&#160;1.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">This Amendment No.&#160;1 does not update or amend
the Company&#8217;s financial statements or any other items in the Original Filing in any way other than as described in the preceding
paragraphs, and the Original Filing, as amended by this Amendment No.&#160;1, continues to speak as of the date of the Original Filing.
Accordingly, this Amendment No.&#160;1 should be read in conjunction with the Original Filing and the Company&#8217;s other filings with
the SEC.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></p>

<!-- Field: Page; Sequence: 2 -->
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<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>PART&#160;IV</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Item&#160;15. &#160;&#160;Exhibits and Financial Statement Schedules</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Financial Statements</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The response to this portion of Item 15 is incorporated by reference
from the Original Filing into this Amendment.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><b>Exhibits</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Those exhibits required to be filed with the Annual Report on Form&#160;10-K
by Item&#160;601 of Regulation&#160;S-K are listed in the exhibit index below.</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><b>Exhibit&#160;Index</b></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr>
    <td style="border-bottom: Black 1pt solid; width: 10%; text-align: center"><span style="font-size: 10pt"><b>Exhibit</b><br />
<b>Number</b></span></td>
    <td style="width: 1%">&#160;</td>
    <td style="border-bottom: Black 1pt solid; vertical-align: bottom; width: 89%; text-align: center"><span style="font-size: 10pt"><b>Description of Exhibit</b></span></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000058/vexhibit21.htm" style="-sec-extract: exhibit">2.1&#8224;&#8224;</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000058/vexhibit21.htm" style="-sec-extract: exhibit">Asset Purchase Agreement, dated March&#160;15, 2017, between PTC Therapeutics,&#160;Inc. and Complete Pharma Holdings, LLC (f/k/a Marathon Pharmaceuticals, LLC) (incorporated by reference to Exhibit&#160;2.1 to the Current Report on Form&#160;8-K filed by the Registrant on March&#160;16, 2017)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
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  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000071/exhibit21_amendmentno1toas.htm" style="-sec-extract: exhibit">2.2</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000071/exhibit21_amendmentno1toas.htm" style="-sec-extract: exhibit">Amendment to Asset Purchase Agreement, dated April&#160;20, 2017, between PTC Therapeutics,&#160;Inc. and Complete Pharma Holdings, LLC (f/k/a Marathon Pharmaceuticals, LLC) (incorporated by reference to Exhibit&#160;2.1 to the Current Report on Form&#160;8-K filed by the Registrant on April&#160;20, 2017)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
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  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465918046031/a18-17399_1ex2d1.htm" style="-sec-extract: exhibit">2.3&#8224;</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465918046031/a18-17399_1ex2d1.htm" style="-sec-extract: exhibit">Agreement and Plan of Merger, dated July&#160;19, 2018, by and among PTC Therapeutics,&#160;Inc., Agility Merger Sub,&#160;Inc., Agilis Biotherapeutics,&#160;Inc. and, solely in its capacity as equityholder representative, Shareholder Representative Services LLC (incorporated by reference to Exhibit&#160;2.1 to the Current Report on Form&#160;8-K filed by the Registrant on July&#160;19, 2018)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000056/mightyapa.htm" style="-sec-extract: exhibit">2.4*</a></td>
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  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr>
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    <td style="vertical-align: bottom; text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465920057485/tm2018807d1_ex2-1.htm" style="-sec-extract: exhibit">Agreement and Plan of Merger, dated May&#160;5, 2020, by and among PTC Therapeutics,&#160;Inc., Hydro Merger Sub,&#160;Inc., Censa Pharmaceuticals Inc. and, solely in its capacity as securityholder representative, Shareholder Representative Services LLC (incorporated by reference to Exhibit&#160;2.1 to the Current Report on Form&#160;8-K filed by the Registrant on May&#160;6, 2020)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000029/ptct-20210630ex312113d92.htm" style="-sec-extract: exhibit">3.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000029/ptct-20210630ex312113d92.htm" style="-sec-extract: exhibit">Restated Certificate of Incorporation of the Registrant, as amended (incorporated by reference to Exhibit&#160;3.1 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on July&#160;29, 2021)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922124889/tm2232094d1_ex3-1.htm" style="-sec-extract: exhibit">3.2</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922124889/tm2232094d1_ex3-1.htm" style="-sec-extract: exhibit">Amended and Restated Bylaws of the Registrant, effective December&#160;5, 2022 (incorporated by reference to Exhibit&#160;3.1 to the Current Report on Form&#160;8-K filed by the Registrant on December&#160;6, 2022)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000011/ptct-20211231ex41769a2d9.htm" style="-sec-extract: exhibit">4.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000011/ptct-20211231ex41769a2d9.htm" style="-sec-extract: exhibit">Description of Registered Securities (incorporated by reference to Exhibit&#160;4.1 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;22, 2022)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-4_1.htm" style="-sec-extract: exhibit">Specimen Stock Certificate evidencing the shares of common stock (incorporated by reference to Exhibit&#160;4.1 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
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<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_4.htm" style="-sec-extract: exhibit">10.1+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_4.htm" style="-sec-extract: exhibit">2009 Equity and Long Term Incentive Plan, as amended (incorporated by reference to Exhibit&#160;10.4 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_5.htm" style="-sec-extract: exhibit">10.2+</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_5.htm" style="-sec-extract: exhibit">Form&#160;of Notice of Award for Incentive Stock Option under 2009 Equity and Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.5 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_6.htm" style="-sec-extract: exhibit">10.3+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_6.htm" style="-sec-extract: exhibit">Form&#160;of Notice of Award for Nonstatutory Stock Option under 2009 Equity and Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.6 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_19.htm" style="-sec-extract: exhibit">10.4+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_19.htm" style="-sec-extract: exhibit">Form&#160;of Restricted Stock Agreement under 2009 Equity and Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.19 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_7.htm" style="-sec-extract: exhibit">10.5+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_7.htm" style="-sec-extract: exhibit">2013 Stock Incentive Plan (incorporated by reference to Exhibit&#160;10.7 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_8.htm" style="-sec-extract: exhibit">10.6+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_8.htm" style="-sec-extract: exhibit">Form&#160;of Restricted Stock Agreement under 2013 Stock Incentive Plan (incorporated by reference to Exhibit&#160;10.8 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_9.htm" style="-sec-extract: exhibit">10.7+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_9.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under 2013 Stock Incentive Plan (incorporated by reference to Exhibit&#160;10.9 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000155837022009860/tmb-20220608xex10d1.htm" style="-sec-extract: exhibit">10.8+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000155837022009860/tmb-20220608xex10d1.htm" style="-sec-extract: exhibit">PTC Therapeutics,&#160;Inc. Amended and Restated 2013 Long-Term Incentive Plan (incorporated by reference to Exhibit&#160;10.1 to the Current Report on Form&#160;8-K filed by the Registrant on June&#160;9, 2022)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_11.htm" style="-sec-extract: exhibit">10.9+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_11.htm" style="-sec-extract: exhibit">Form&#160;of Incentive Stock Option Agreement under 2013 Long Term Incentive Plan&#8212;2013/2014 (incorporated by reference to Exhibit&#160;10.11 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_12.htm" style="-sec-extract: exhibit">10.10+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_12.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under 2013 Long Term Incentive Plan&#8212;2013/2014 (incorporated by reference to Exhibit&#160;10.12 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_14.htm" style="-sec-extract: exhibit">10.11+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_14.htm" style="-sec-extract: exhibit">Form&#160;of Nonqualified Stock Option Agreement Inducement Grant Agreement&#8212;2014-2022 (incorporated by reference to Exhibit&#160;10.14 to the Annual Report on Form&#160;10-K filed by the Registrant on March&#160;2, 2015)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_15.htm" style="-sec-extract: exhibit">10.12+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_15.htm" style="-sec-extract: exhibit">Form&#160;of Incentive Stock Option Agreement under 2013 Long Term Incentive Plan&#8212;2014-2022 (incorporated by reference to Exhibit&#160;10.15 to the Annual Report on Form&#160;10-K filed by the Registrant on March&#160;2, 2015)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_16.htm" style="-sec-extract: exhibit">10.13+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746915001457/a2223091zex-10_16.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under 2013 Long Term Incentive Plan&#8212;2014-2022 (incorporated by reference to Exhibit&#160;10.16 to the Annual Report on Form&#160;10-K filed by the Registrant on March&#160;2, 2015)</a></td></tr>
</table>

<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr>
    <td style="border-bottom: Black 1pt solid; text-align: center"><span style="font-size: 10pt"><b>Exhibit</b><br />
<b>Number</b></span></td>
    <td>&#160;</td>
    <td style="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><span style="font-size: 10pt"><b>Description of Exhibit</b></span></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right; width: 10%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746916010589/a2227494zex-10_31.htm" style="-sec-extract: exhibit">10.14+</a></td>
    <td style="width: 1%">&#160;</td>
    <td style="text-align: justify; width: 89%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746916010589/a2227494zex-10_31.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under 2013 Long Term Incentive Plan&#8212;Non-employee Director (incorporated by reference to Exhibit&#160;10.31 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;29, 2016)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746916010589/a2227494zex-10_32.htm" style="-sec-extract: exhibit">10.15+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746916010589/a2227494zex-10_32.htm" style="-sec-extract: exhibit">Form&#160;of Restricted Stock Unit Agreement under 2013 Long Term Incentive Plan &#8212;2016-2022 (incorporated by reference to Exhibit&#160;10.32 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;29, 2016)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000062/exhibit1019rsa.htm" style="-sec-extract: exhibit">10.16+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000062/exhibit1019rsa.htm" style="-sec-extract: exhibit">Form&#160;of Restricted Stock Agreement under 2013 Long Term Incentive Plan &#8212;2017-2022 (incorporated by reference to Exhibit&#160;10.19 to the Annual Report on Form&#160;10-K filed by the Registrant on March&#160;16, 2017)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000002/ex993-inducexrsu_final.htm" style="-sec-extract: exhibit">10.17+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000002/ex993-inducexrsu_final.htm" style="-sec-extract: exhibit">Form&#160;of Nonqualified Restricted Stock Award Agreement Inducement Grant Agreement-2018 (incorporated by reference to Exhibit&#160;99.3 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-229126), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d18.htm" style="-sec-extract: exhibit">10.18+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d18.htm" style="-sec-extract: exhibit">Form&#160;of Incentive Stock Option Agreement under Amended and Restated 2013 Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.18 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d19.htm" style="-sec-extract: exhibit">10.19+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d19.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under Amended and Restated 2013 Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.19 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d20.htm" style="-sec-extract: exhibit">10.20+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d20.htm" style="-sec-extract: exhibit">Form&#160;of Nonstatutory Stock Option Agreement under Amended and Restated 2013 Long Term Incentive Plan&#8212;Non-employee Director (incorporated by reference to Exhibit&#160;10.20 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d21.htm" style="-sec-extract: exhibit">10.21+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d21.htm" style="-sec-extract: exhibit">Form&#160;of Restricted Stock Unit Agreement under Amended and Restated 2013 Long Term Incentive Plan (incorporated by reference to Exhibit&#160;10.21 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_16.htm" style="-sec-extract: exhibit">10.22&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_16.htm" style="-sec-extract: exhibit">Funding Agreement, dated as of May&#160;26, 2010, by and between the Registrant and The Wellcome Trust Limited (incorporated by reference to Exhibit&#160;10.16 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d23.htm" style="-sec-extract: exhibit">10.23*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d23.htm" style="-sec-extract: exhibit">Amendments to the Funding Agreement, dated as of May&#160;26, 2010, by and between the Registrant and The Wellcome Trust Limited (incorporated by reference to Exhibit&#160;10.23 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_20.htm" style="-sec-extract: exhibit">10.24+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_20.htm" style="-sec-extract: exhibit">Amended and Restated Employment Agreement between the Registrant and Stuart W. Peltz (incorporated by reference to Exhibit&#160;10.20 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_22.htm" style="-sec-extract: exhibit">10.25+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_22.htm" style="-sec-extract: exhibit">Amended and Restated Employment Agreement between the Registrant and Mark E. Boulding (incorporated by reference to Exhibit&#160;10.22 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_24.htm" style="-sec-extract: exhibit">10.26+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006525/a2215427zex-10_24.htm" style="-sec-extract: exhibit">Amended and Restated Employment Agreement between the Registrant and Neil Almstead (incorporated by reference to Exhibit&#160;10.24 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333-188657), of the Registrant)</a></td></tr>
</table>

<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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  <tr>
    <td style="border-bottom: Black 1pt solid; text-align: center"><span style="font-size: 10pt"><b>Exhibit</b><br />
<b>Number</b></span></td>
    <td>&#160;</td>
    <td style="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><span style="font-size: 10pt"><b>Description of Exhibit</b></span></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right; width: 10%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000117/exhibit101faesagreement.htm" style="-sec-extract: exhibit">10.27&#8224;</a></td>
    <td style="width: 1%">&#160;</td>
    <td style="text-align: justify; width: 89%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008117000117/exhibit101faesagreement.htm" style="-sec-extract: exhibit">Exclusive License and Supply Agreement, dated as of May&#160;12, 2015, as amended, by and between Faes Farma, S.A. and Complete Pharma Holdings, LLC (f/k/a Marathon Pharmaceuticals, LLC), as assigned by Complete Pharma Holdings, LLC to the Registrant on April&#160;20, 2017 (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;9, 2017)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000017/ptct-20220331ex102aadcc2.htm" style="-sec-extract: exhibit">10.28&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000017/ptct-20220331ex102aadcc2.htm" style="-sec-extract: exhibit">Commercial Manufacturing Agreement, dated as of September&#160;18, 2015, as amended, by and between Alcami Corporation (f/k/a/ AAI Pharma Services Corp.) and Complete Pharma Holdings, LLC (f/k/a Marathon Pharmaceuticals, LLC), as assigned by Complete Pharma Holdings, LLC to the Registrant on April&#160;20, 2017 (incorporated by reference to Exhibit&#160;10.2 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on May&#160;3, 2022)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000050/exhibit102utteremploym.htm" style="-sec-extract: exhibit">10.29+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000050/exhibit102utteremploym.htm" style="-sec-extract: exhibit">Employment Agreement, as amended, between the Registrant and Christine Utter (incorporated by reference to Exhibit&#160;10.2 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;6, 2019)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008118000077/ex104ptcntulicenseandtecht.htm" style="-sec-extract: exhibit">10.30&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008118000077/ex104ptcntulicenseandtecht.htm" style="-sec-extract: exhibit">License and Technology Transfer Agreement, dated December&#160;23, 2015, by and among National Taiwan University, Professor Wuh-Lian(Paul) Hwu and Agilis Biotherapeutics,&#160;Inc. (formerly Agilis Biotherapeutics, LLC) (incorporated by reference to Exhibit&#160;10.3 on Form&#160;10-Q filed by Registrant on November&#160;5, 2018)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000064/exhibit1042ntuamendmen.htm" style="-sec-extract: exhibit">10.31*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000064/exhibit1042ntuamendmen.htm" style="-sec-extract: exhibit">License and Technology Transfer Agreement Amendment No.&#160;2, dated December&#160;1, 2019, by and among National Taiwan University, Professor Wu-Lian (Paul) Hwu and PTC Therapeutics GT,&#160;Inc. (incorporated by reference to Exhibit&#160;10.42 on Form&#160;10-K filed by Registrant on March&#160;2, 2020)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008118000077/ex105ptcakceacollaboration.htm" style="-sec-extract: exhibit">10.32&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008118000077/ex105ptcakceacollaboration.htm" style="-sec-extract: exhibit">Collaboration and License Agreement, dated August&#160;1, 2018, by and between PTC Therapeutics International Limited and Akcea Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.3 on Form&#160;10-Q filed by Registrant on November&#160;5, 2018)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000020/ptct-20210608ex10141119a.htm" style="-sec-extract: exhibit">10.33</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000020/ptct-20210608ex10141119a.htm" style="-sec-extract: exhibit">Amended and Restated 2016 Employee Stock Purchase Plan (incorporated by reference to Exhibit&#160;10.1 to the Current Report on Form&#160;8-K filed by the Registrant on June&#160;9, 2021)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000050/ex101employmentagreeme.htm" style="-sec-extract: exhibit">10.34+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000050/ex101employmentagreeme.htm" style="-sec-extract: exhibit">Employment Agreement, as amended, between the Registrant and Emily Hill (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;6, 2019)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000057/bmslease.htm" style="-sec-extract: exhibit">10.35*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000057/bmslease.htm" style="-sec-extract: exhibit">Lease Agreement dated as of August&#160;3, 2019, by and between Bristol-Myers Squibb Company and PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.5 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on October&#160;30, 2019)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000057/hsbcletterofcredit.htm" style="-sec-extract: exhibit">10.36</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008119000057/hsbcletterofcredit.htm" style="-sec-extract: exhibit">Irrevocable Standby Letter of Credit, dated September&#160;3, 2019, issued by HSBC Bank USA, N.A. in favor of Bristol-Myers Squibb Company for the Account of PTC Therapeutics,&#160;Inc., as amended (incorporated by reference to Exhibit&#160;10.6 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on October&#160;30, 2019)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a993inducementplan.htm" style="-sec-extract: exhibit">10.37+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a993inducementplan.htm" style="-sec-extract: exhibit">2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.3 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-235823), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a994optionagreement.htm" style="-sec-extract: exhibit">10.38+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a994optionagreement.htm" style="-sec-extract: exhibit">Form&#160;of Inducement Option Agreement under the 2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.4 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-235823), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a995rsuagreement.htm" style="-sec-extract: exhibit">10.39+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000004/a995rsuagreement.htm" style="-sec-extract: exhibit">Form&#160;of Inducement Restricted Stock Agreement under the 2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.5 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-235823), of the Registrant)</a></td></tr>
</table>

<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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<p style="margin: 0">&#160;</p>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <tr>
    <td style="border-bottom: Black 1pt solid; text-align: center"><span style="font-size: 10pt"><b>Exhibit</b><br />
<b>Number</b></span></td>
    <td>&#160;</td>
    <td style="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center"><span style="font-size: 10pt"><b>Description of Exhibit</b></span></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right; width: 10%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000003/ptct-20210104ex99381725f.htm" style="-sec-extract: exhibit">10.40+</a></td>
    <td style="width: 1%">&#160;</td>
    <td style="text-align: justify; width: 89%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008121000003/ptct-20210104ex99381725f.htm" style="-sec-extract: exhibit">Amendment No.&#160;1 to 2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.3 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-251878) of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922045499/tm2212549d1_ex99-1.htm" style="-sec-extract: exhibit">10.41+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922045499/tm2212549d1_ex99-1.htm" style="-sec-extract: exhibit">Amendment No.&#160;2 to 2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.1 to Post-Effective Amendment No.&#160;1 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-251878) of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922127902/tm2232864d3_ex99-4.htm" style="-sec-extract: exhibit">10.42+</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000110465922127902/tm2232864d3_ex99-4.htm" style="-sec-extract: exhibit">Amendment No.&#160;3 to 2020 Inducement Stock Incentive Plan (incorporated by reference to Exhibit&#160;99.4 to the Registration Statement on Form&#160;S-8 (File No.&#160;333-268851), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000064/exhibit1051firstamendm.htm" style="-sec-extract: exhibit">10.43*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000064/exhibit1051firstamendm.htm" style="-sec-extract: exhibit">First Amendment to Lease Agreement dated as of October&#160;7, 2019 by and between Bristol-Myers Squibb Company and PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.51 to the Annual Report on Form&#160;10-K filed by the Registrant on March&#160;2, 2020)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000096/bmssecondamendment.htm" style="-sec-extract: exhibit">10.44*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000096/bmssecondamendment.htm" style="-sec-extract: exhibit">Second Amendment to Lease Agreement dated as of March&#160;25, 2020 by and between Bristol-Myers Squibb Company and PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on April&#160;30, 2020)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000128/ex101shiratorilicensea.htm" style="-sec-extract: exhibit">10.45*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000128/ex101shiratorilicensea.htm" style="-sec-extract: exhibit">License Agreement dated as of February&#160;8, 2016, as amended, by and between Shiratori Pharmaceutical Co. Ltd. and Censa Pharmaceuticals Inc. (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;5, 2020)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000128/ex102rpiroyaltypurchas.htm" style="-sec-extract: exhibit">10.46*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000128/ex102rpiroyaltypurchas.htm" style="-sec-extract: exhibit">Royalty Purchase Agreement, dated as of July&#160;17, 2020, by and among PTC Therapeutics,&#160;Inc., RPI 2019 Intermediate Finance Trust, and, solely for the limited purposes set forth therein, Royalty Pharma PLC (incorporated by reference to Exhibit&#160;10.2 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;5, 2020)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
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  <tr style="vertical-align: top">
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000011/ptct-20211231ex1044a6165.htm" style="-sec-extract: exhibit">Employment Agreement, as amended, between the Registrant and Matthew Klein (incorporated by reference to Exhibit&#160;10.44 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;22, 2022)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000128/ex104pauwelsemployment.htm" style="-sec-extract: exhibit">Employment Agreement, as amended, between the Registrant and Eric Pauwels (incorporated by reference to Exhibit&#160;10.4 to the Quarterly Report on Form&#160;10-Q filed by the Registrant on August&#160;5, 2020)</a></td></tr>
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    <td>&#160;</td>
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    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000095/rightsexchangeagreement.htm" style="-sec-extract: exhibit">10.49*</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008120000095/rightsexchangeagreement.htm" style="-sec-extract: exhibit">Rights Exchange Agreement, by and among PTC Therapeutics,&#160;Inc., the Rightholders set forth therein, and, for the limited purposes set forth therein, Shareholder Representatives Services LLC, dated as of April&#160;29, 2020 (incorporated by reference to Exhibit&#160;10.1 to the Current Report on Form&#160;8-K filed by the Registrant on April&#160;30, 2020)</a></td></tr>
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    <td>&#160;</td>
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  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000141057819000703/tv526852_ex1-1.htm" style="-sec-extract: exhibit">10.50</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000141057819000703/tv526852_ex1-1.htm" style="-sec-extract: exhibit">At the Market Offering Sales Agreement, dated August&#160;7, 2019, among PTC Therapeutics,&#160;Inc., Cantor Fitzgerald&#160;&amp; Co. and RBC Capital Markets, LLC (incorporated by reference to Exhibit&#160;1.1 to the Current Report on Form&#160;8-K filed by the Registrant on August&#160;7, 2019)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
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  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000031/tmb-20220630xex10d1.htm" style="-sec-extract: exhibit">10.51*</a></td>
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000031/tmb-20220630xex10d1.htm" style="-sec-extract: exhibit">Lease Agreement dated May&#160;24, 2022, between Warren CC Acquisitions, LLC and PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by Registrant on August&#160;4, 2022)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
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  <tr style="vertical-align: top">
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    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000031/tmb-20220630xex10d2.htm" style="-sec-extract: exhibit">Irrevocable Transferable Standby Letter of Credit, dated June&#160;22, 2022, issued by HSBC Bank USA, N.A. in favor of Warren CC Acquisitions LLC c/o Vision Real Estate Partners for the Account of PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.2 to the Quarterly Report on Form&#160;10-Q filed by Registrant on August&#160;4, 2022)</a></td></tr>
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<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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  <tr>
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<tr style="vertical-align: top">
    <td style="text-align: right; width: 10%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000041/tmb-20221027xex10d1.htm" style="-sec-extract: exhibit">10.53*</a></td>
    <td style="width: 1%">&#160;</td>
    <td style="text-align: justify; width: 89%"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000041/tmb-20221027xex10d1.htm" style="-sec-extract: exhibit">Letter Agreement re: Collaboration and License Agreement, dated July&#160;25, 2022, by and between Akcea Therapeutics,&#160;Inc. and PTC Therapeutics International Limited (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by Registrant on October&#160;27, 2022)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000041/tmb-20221027xex10d2.htm" style="-sec-extract: exhibit">10.54*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008122000041/tmb-20221027xex10d2.htm" style="-sec-extract: exhibit">Letter Agreement re: Collaboration and License Agreement, dated September&#160;14, 2022, by and between Akcea Therapeutics,&#160;Inc. and PTC Therapeutics International Limited (incorporated by reference to Exhibit&#160;10.1 to the Quarterly Report on Form&#160;10-Q filed by Registrant on October&#160;27, 2022)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d55.htm" style="-sec-extract: exhibit">10.55*</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d55.htm" style="-sec-extract: exhibit">Credit Agreement dated as of October&#160;27, 2022, among PTC Therapeutics,&#160;Inc., as the Borrower, each subsidiary of the Borrower from time to time party thereto, as Guarantors, the Lenders from time to time party thereto and Wilmington Trust, National Association, as Administrative Agent (incorporated by reference to Exhibit&#160;10.55 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d56.htm" style="-sec-extract: exhibit">10.56</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex10d56.htm" style="-sec-extract: exhibit">Stock Purchase Agreement, dated as of October&#160;27, 2022 by and among the investors listed therein and PTC Therapeutics,&#160;Inc. (incorporated by reference to Exhibit&#160;10.56 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_13.htm" style="-sec-extract: exhibit">10.57</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_13.htm" style="-sec-extract: exhibit">Lease Agreement, dated as of July&#160;11, 2000, as amended, between the Registrant and 46.24 Associates L.P. (incorporated by reference to Exhibit&#160;10.13 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333 188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_14.htm" style="-sec-extract: exhibit">10.58&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_14.htm" style="-sec-extract: exhibit">License and Collaboration Agreement, dated as of November&#160;23, 2011, as amended, by and among the Registrant, F. Hoffmann-La Roche Ltd and Hoffmann-La Roche,&#160;Inc. and Spinal Muscular Atrophy Foundation (incorporated by reference to Exhibit&#160;10.14 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333 188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_15.htm" style="-sec-extract: exhibit">10.59&#8224;</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000104746913006241/a2215112zex-10_15.htm" style="-sec-extract: exhibit">Sponsored Research Agreement, as amended dated as of June&#160;1, 2006, by and between the Registrant and Spinal Muscular Atrophy Foundation (incorporated by reference to Exhibit&#160;10.15 to the Registration Statement on Form&#160;S-1, as amended (File No.&#160;333 188657), of the Registrant)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex21d1.htm" style="-sec-extract: exhibit">21.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex21d1.htm" style="-sec-extract: exhibit">Subsidiaries of the Registrant (incorporated by reference to Exhibit&#160;21.1 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex23d1.htm" style="-sec-extract: exhibit">23.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex23d1.htm" style="-sec-extract: exhibit">Consent of Independent Registered Public Accounting Firm (incorporated by reference to Exhibit&#160;23.1 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231x10k.htm#PowerofAttorney" style="-sec-extract: exhibit">24.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231x10k.htm#PowerofAttorney" style="-sec-extract: exhibit">Power of attorney (included on the signature page&#160;to this Form&#160;10-K)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex31d1.htm" style="-sec-extract: exhibit">31.1</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex31d1.htm" style="-sec-extract: exhibit">Certification of Principal Executive Officer pursuant to Rule&#160;13a-14(a)&#160;or Rule&#160;15d-14(a)&#160;of the Securities Exchange Act of 1934, as adopted pursuant to Section&#160;302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit&#160;31.1 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex31d2.htm" style="-sec-extract: exhibit">31.2</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex31d2.htm" style="-sec-extract: exhibit">Certification of Principal Financial Officer pursuant to Rule&#160;13a-14(a)&#160;or Rule&#160;15d-14(a)&#160;of the Securities Exchange Act of 1934, as adopted pursuant to Section&#160;302 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit&#160;31.2 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: right"><a href="tm238714d1_ex31-3.htm">31.3</a></td>
    <td>&#160;</td>
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</table>

<p style="margin: 0">&#160;</p>

<p style="margin: 0"></p>

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  <tr>
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<b>Number</b></span></td>
    <td style="width: 1%">&#160;</td>
    <td style="border-bottom: Black 1pt solid; vertical-align: bottom; text-align: center; width: 89%"><span style="font-size: 10pt"><b>Description of Exhibit</b></span></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify"><a href="tm238714d1_ex31-4.htm">Certification of Principal Financial Officer pursuant to Rule&#160;13a-14(a)&#160;or Rule&#160;15d-14(a)&#160;of the Securities Exchange Act of 1934, as adopted pursuant to Section&#160;302 of the Sarbanes-Oxley Act of 2002**</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex32d1.htm" style="-sec-extract: exhibit">Certification of Principal Executive Officer pursuant to 18 U.S.C. Section&#160;1350, as adopted pursuant to Section&#160;906 of the Sarbanes-Oxley Act of 2002 (incorporated by reference to Exhibit&#160;32.1 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex32d2.htm" style="-sec-extract: exhibit">32.2</a></td>
    <td>&#160;</td>
    <td style="text-align: justify"><a href="https://www.sec.gov/Archives/edgar/data/1070081/000107008123000011/tmb-20221231xex32d2.htm" style="-sec-extract: exhibit">Certification of Principal Financial Officer pursuant to 18 U.S.C. Section&#160;1350, as adopted pursuant to Section&#160;906 of the Sarbanes-Oxley Act of 2002 (incorporate by reference to Exhibit&#160;32.2 to the Annual Report on Form&#160;10-K filed by the Registrant on February&#160;21, 2023)</a></td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
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    <td>&#160;</td>
    <td style="text-align: justify">Inline XBRL Instance Document</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">101.SCH</td>
    <td>&#160;</td>
    <td style="text-align: justify">Inline XBRL Taxonomy Extension Schema Document</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">101.CAL</td>
    <td>&#160;</td>
    <td style="text-align: justify">Inline XBRL Taxonomy Extension Calculation Linkbase Document</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">101.LAB</td>
    <td>&#160;</td>
    <td style="text-align: justify">Inline XBRL Taxonomy Extension Label Linkbase Database</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">&#160;</td>
    <td>&#160;</td>
    <td style="text-align: justify">&#160;</td></tr>
  <tr style="vertical-align: top">
    <td style="text-align: right">101.PRE</td>
    <td>&#160;</td>
    <td style="text-align: justify">Inline XBRL Taxonomy Extension Presentation Linkbase Document</td></tr>
  <tr style="vertical-align: top">
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      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentAnnualReport" xlink:label="dei_DocumentAnnualReport" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentAnnualReport_lbl" xml:lang="en-US">Document Annual Report</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentQuarterlyReport_lbl" xml:lang="en-US">Document Quarterly Report</link:label>
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      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentShellCompanyReport" xlink:label="dei_DocumentShellCompanyReport" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentShellCompanyEventDate_lbl" xml:lang="en-US">Document Shell Company Event Date</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentPeriodStartDate_lbl" xml:lang="en-US">Document Period Start Date</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentPeriodEndDate_lbl" xml:lang="en-US">Document Period End Date</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="dei_DocumentFiscalPeriodFocus" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_DocumentFiscalYearFocus_lbl" xml:lang="en-US">Document Fiscal Year Focus</link:label>
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      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber" xlink:label="dei_EntityFileNumber" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityFileNumber_lbl" xml:lang="en-US">Entity File Number</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityRegistrantName_lbl" xml:lang="en-US">Entity Registrant Name</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey" />
      <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey_lbl" xlink:type="arc" />
      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityCentralIndexKey_lbl" xml:lang="en-US">Entity Central Index Key</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityPrimarySicNumber" xlink:label="dei_EntityPrimarySicNumber" />
      <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityPrimarySicNumber" xlink:to="dei_EntityPrimarySicNumber_lbl" xlink:type="arc" />
      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityPrimarySicNumber_lbl" xml:lang="en-US">Entity Primary SIC Number</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityTaxIdentificationNumber" xlink:label="dei_EntityTaxIdentificationNumber" />
      <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber_lbl" xlink:type="arc" />
      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xml:lang="en-US">Entity Tax Identification Number</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode" xlink:label="dei_EntityIncorporationStateCountryCode" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xml:lang="en-US">Entity Incorporation, State or Country Code</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1" xlink:label="dei_EntityAddressAddressLine1" />
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityAddressAddressLine1_lbl" xml:lang="en-US">Entity Address, Address Line One</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityAddressAddressLine2_lbl" xml:lang="en-US">Entity Address, Address Line Two</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityAddressCityOrTown_lbl" xml:lang="en-US">Entity Address, City or Town</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_EntityAddressStateOrProvince_lbl" xml:lang="en-US">Entity Address, State or Province</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_CountryRegion_lbl" xml:lang="en-US">Country Region</link:label>
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      <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_WrittenCommunications" xlink:to="dei_WrittenCommunications_lbl" xlink:type="arc" />
      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_WrittenCommunications_lbl" xml:lang="en-US">Written Communications</link:label>
      <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_SolicitingMaterial" xlink:label="dei_SolicitingMaterial" />
      <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_SolicitingMaterial" xlink:to="dei_SolicitingMaterial_lbl" xlink:type="arc" />
      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_SolicitingMaterial_lbl" xml:lang="en-US">Soliciting Material</link:label>
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      <link:label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_Security12bTitle_lbl" xml:lang="en-US">Title of 12(b) Security</link:label>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>6
<FILENAME>ptct-20221231_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
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<span style="display: none;">v3.22.4</span><table class="report" border="0" cellspacing="2" id="idm140102260508608">
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<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Cover - USD ($)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
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<th class="th" colspan="1"></th>
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<tr>
<th class="th"><div>Dec. 31, 2022</div></th>
<th class="th"><div>Feb. 16, 2023</div></th>
<th class="th"><div>Jun. 30, 2022</div></th>
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<td class="text">This Amendment No.&#160;1 on Form&#160;10-K/A
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2023 (the &#8220;Original Filing&#8221;), is being filed solely for the purpose of amending Item 15, Exhibits and Financial Statement
Schedules, of Part&#160;IV, to add reference to new Exhibits 10.57, 10.58 and 10.59. References in the exhibit index to these exhibits,
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Dec. 31,  2022<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentFiscalPeriodFocus', window );">Document Fiscal Period Focus</a></td>
<td class="text">FY<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentFiscalYearFocus', window );">Document Fiscal Year Focus</a></td>
<td class="text">2022<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CurrentFiscalYearEndDate', window );">Current Fiscal Year End Date</a></td>
<td class="text">--12-31<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">001-35969<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">PTC THERAPEUTICS,&#160;INC.<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001070081<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">04-3416587<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">100 Corporate Court<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">South Plainfield<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">NJ<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">07080<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">908<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">222-7000<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock, $0.001 par value per share<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PTCT<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
<td class="text">&#160;<span></span>
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<td class="text">Yes<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityVoluntaryFilers', window );">Entity Voluntary Filers</a></td>
<td class="text">No<span></span>
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<td class="text">Yes<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityInteractiveDataCurrent', window );">Entity Interactive Data Current</a></td>
<td class="text">Yes<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFilerCategory', window );">Entity Filer Category</a></td>
<td class="text">Large Accelerated Filer<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntitySmallBusiness', window );">Entity Small Business</a></td>
<td class="text">false<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityShellCompany', window );">Entity Shell Company</a></td>
<td class="text">false<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityPublicFloat', window );">Entity Public Float</a></td>
<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="nump">$ 2,129,532,394<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCommonStockSharesOutstanding', window );">Entity Common Stock, Shares Outstanding</a></td>
<td class="text">&#160;<span></span>
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<td class="nump">73,815,144<span></span>
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<td class="text">&#160;<span></span>
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</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentsIncorporatedByReferenceTextBlock', window );">Documents Incorporated by Reference [Text Block]</a></td>
<td class="text">

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="background-color: white"><b>DOCUMENTS INCORPORATED BY REFERENCE</b></span></p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&#160;</p>

<p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><span style="background-color: white">Part&#160;III of this Annual Report incorporates by reference information from the definitive Proxy Statement for the registrant&#8217;s 2023 Annual Meeting of Shareholders which is expected to be filed with the Securities and Exchange Commission not later than 120&#160;days after the registrant&#8217;s fiscal&#160;year ended December&#160;31, 2022.</span></p>

<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_IcfrAuditorAttestationFlag', window );">ICFR Auditor Attestation Flag</a></td>
<td class="text">true<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AuditorName', window );">Auditor Name</a></td>
<td class="text">Ernst & Young LLP<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
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<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AuditorFirmId', window );">Auditor Firm ID</a></td>
<td class="text">42<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AuditorLocation', window );">Auditor Location</a></td>
<td class="text">Location Iselin, New Jersey<span></span>
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<td class="text">&#160;<span></span>
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<td class="text">&#160;<span></span>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Description of changes contained within amended document.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>PCAOB issued Audit Firm Identifier</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 10-K<br> -Number 249<br> -Section 310<br><br>Reference 2: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 20-F<br> -Number 249<br> -Section 220<br> -Subsection f<br><br>Reference 3: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 40-F<br> -Number 249<br> -Section 240<br> -Subsection f<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AuditorFirmId</td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 10-K<br> -Number 249<br> -Section 310<br><br>Reference 2: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 20-F<br> -Number 249<br> -Section 220<br> -Subsection f<br><br>Reference 3: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 40-F<br> -Number 249<br> -Section 240<br> -Subsection f<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AuditorLocation</td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 10-K<br> -Number 249<br> -Section 310<br><br>Reference 2: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 20-F<br> -Number 249<br> -Section 220<br> -Subsection f<br><br>Reference 3: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 40-F<br> -Number 249<br> -Section 240<br> -Subsection f<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AuditorName</td>
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<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
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<td><strong> Data Type:</strong></td>
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<td><strong> Balance Type:</strong></td>
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<td><strong> Period Type:</strong></td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
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<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>End date of current fiscal year in the format --MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CurrentFiscalYearEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
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<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:gMonthDayItemType</td>
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<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
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</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentAnnualReport">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true only for a form used as an annual report.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 10-K<br> -Number 249<br> -Section 310<br><br>Reference 2: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 20-F<br> -Number 249<br> -Section 220<br> -Subsection f<br><br>Reference 3: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 40-F<br> -Number 249<br> -Section 240<br> -Subsection f<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentAnnualReport</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentFiscalPeriodFocus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Fiscal period values are FY, Q1, Q2, and Q3.  1st, 2nd and 3rd quarter 10-Q or 10-QT statements have value Q1, Q2, and Q3 respectively, with 10-K, 10-KT or other fiscal year statements having FY.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentFiscalPeriodFocus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fiscalPeriodItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentFiscalYearFocus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>This is focus fiscal year of the document report in YYYY format. For a 2006 annual report, which may also provide financial information from prior periods, fiscal 2006 should be given as the fiscal year focus. Example: 2006.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentFiscalYearFocus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:gYearItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentTransitionReport">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true only for a form used as a transition report.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Forms 10-K, 10-Q, 20-F<br> -Number 240<br> -Section 13<br> -Subsection a-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentTransitionReport</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
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<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentsIncorporatedByReferenceTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Documents incorporated by reference.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-23<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentsIncorporatedByReferenceTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dtr-types:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
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<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCommonStockSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate number of shares or other units outstanding of each of registrant's classes of capital or common stock or other ownership interests, if and as stated on cover of related periodic report. Where multiple classes or units exist define each class/interest by adding class of stock items such as Common Class A [Member], Common Class B [Member] or Partnership Interest [Member] onto the Instrument [Domain] of the Entity Listings, Instrument.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCommonStockSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCurrentReportingStatus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' whether registrants (1) have filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that registrants were required to file such reports), and (2) have been subject to such filing requirements for the past 90 days. This information should be based on the registrant's current or most recent filing containing the related disclosure.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCurrentReportingStatus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFilerCategory">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate whether the registrant is one of the following: Large Accelerated Filer, Accelerated Filer, Non-accelerated Filer. Definitions of these categories are stated in Rule 12b-2 of the Exchange Act. This information should be based on the registrant's current or most recent filing containing the related disclosure.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFilerCategory</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:filerCategoryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityInteractiveDataCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-T<br> -Number 232<br> -Section 405<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityInteractiveDataCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityPublicFloat">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common equity was last sold, or the average bid and asked price of such common equity, as of the last business day of the registrant's most recently completed second fiscal quarter.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityPublicFloat</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityShellCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the registrant is a shell company as defined in Rule 12b-2 of the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityShellCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntitySmallBusiness">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicates that the company is a Smaller Reporting Company (SRC).</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntitySmallBusiness</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityVoluntaryFilers">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityVoluntaryFilers</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityWellKnownSeasonedIssuer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Is used on Form Type: 10-K, 10-Q, 8-K, 20-F, 6-K, 10-K/A, 10-Q/A, 20-F/A, 6-K/A, N-CSR, N-Q, N-1A.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 405<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityWellKnownSeasonedIssuer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_IcfrAuditorAttestationFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 10-K<br> -Number 249<br> -Section 310<br><br>Reference 2: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 20-F<br> -Number 249<br> -Section 220<br> -Subsection f<br><br>Reference 3: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Form 40-F<br> -Number 249<br> -Section 240<br> -Subsection f<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_IcfrAuditorAttestationFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
