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v3.23.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Cash flows from operating activities |  |
Net loss | $ (138,959) | $ (126,726)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 42,825 | 26,314
Non-cash operating lease expense | 2,942 | 1,908
Non-cash royalty revenue related to sale of future royalties | (13,237) | (8,113)
Non-cash interest expense on liability related to sale of future royalties | 18,902 | 18,874
Change in valuation of deferred and contingent consideration | 2,400 | (11,700)
Unrealized loss (gain) on ClearPoint Equity Investments | 39 | 1,049
Unrealized (gain) loss on ClearPoint convertible debt security | (59) | 1,542
Unrealized (gain) loss on marketable securities - equity investments | (2,166) | 6,477
Disposal of asset |  | 79
Amortization of (discounts) premiums on investments, net | (85) | 887
Deferred income taxes | (4) |
Amortization of debt issuance costs | 438 | 464
Share-based compensation expense | 28,815 | 26,589
Unrealized foreign currency transaction (gains) losses, net | (10,057) | 2,135
Changes in operating assets and liabilities: |  |
Inventory, net | (4,612) | 350
Prepaid expenses and other current assets | 57,611 | 25,118
Trade and royalty receivables, net | (43,426) | (28,372)
Deposits and other assets | 743 | (510)
Accounts payable and accrued expenses | 33,524 | (30,680)
Other liabilities | (3,988) | (3,089)
Deferred revenue | (1,137) |
Net cash used in operating activities | (29,491) | (97,404)
Cash flows from investing activities |  |
Purchases of fixed assets | (10,270) | (9,312)
Purchases of marketable securities - available for sale |  | (39,035)
Sale and redemption of marketable securities- available for sale | 12,500 | 167,101
Sale and redemption of marketable securities - equity investments | 2,196 | 2,423
Acquisition of product rights and licenses | (33,397) | (72,134)
Net cash (used in) provided by investing activities | (28,971) | 49,043
Cash flows from financing activities |  |
Proceeds from exercise of options | 5,655 | 2,444
Debt issuance costs related to secured term loan | (182) |
Payment of finance lease principal | (1,379) | (1,276)
Net cash provided by financing activities | 4,094 | 1,168
Effect of exchange rate changes on cash | (7,963) | 1,653
Net decrease in cash and cash equivalents | (62,331) | (45,540)
Cash and cash equivalents, and restricted cash beginning of period | 295,925 | 197,218
Cash and cash equivalents, and restricted cash end of period | 233,594 | 151,678
Supplemental disclosure of cash information |  |
Cash paid for interest | 12,956 | 6,130
Cash paid for income taxes | 2,215 | 1,987
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain (loss) on marketable securities, net of tax | 54 | (2,913)
Right-of-use assets obtained in exchange for operating lease obligations |  | 587
Acquisition of product rights and licenses | 19,406 | $ 12,589
Debt issuance costs related to senior secured term loan | 45 |
Capital expenditures unpaid at the end of period | 28 |
Milestone payable | $ 32,500 |

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