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v3.23.1

Commitments and contingencies - Narrative (Details) $ / shares in Units, $ in Thousands |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Apr. 29, 2020 USD ($) | Mar. 31, 2023 USD ($) D $ / shares | Jun. 30, 2016 USD ($) | Dec. 31, 2022 USD ($) | May 29, 2020 USD ($)
Other Commitments |  |  |  |  |
Milestone payable |  | $ 32,500 |  |  |
Accrued royalties |  | 32,694 |  | $ 40,546 |
Wellcome Trust |  |  |  |  |
Other Commitments |  |  |  |  |
Development milestone payment obligations |  |  |  | 2,500 |
Milestone obligation payments made |  |  | $ 800 |  |
Censa |  |  |  |  |
Other Commitments |  |  |  |  |
Milestone payable opted to be paid through issuance of common stock |  | $ 30,000 |  |  |
Weighted average stock price | $ / shares |  | $ 44.9748 |  |  |
Consecutive trading days used in determining weighted average stock price | D |  | 30 |  |  |
Asset acquisition, development and regulatory milestones |  |  |  |  | $ 109,000
Asset acquisition, initial milestone |  |  |  |  | 30,000
Censa | Maximum |  |  |  |  |
Other Commitments |  |  |  |  |
Asset acquisition, milestone, amount |  |  |  |  | 217,500
Asset acquisition, net sales milestone |  |  |  |  | $ 160,000
Censa | Accounts payable and accrued expenses |  |  |  |  |
Other Commitments |  |  |  |  |
Milestone payable |  | $ 30,000 |  |  |
SMA License Agreement | SMA Foundation |  |  |  |  |
Other Commitments |  |  |  |  |
Royalty expense |  | 31,600 |  |  |
Royalty payments |  | 24,500 |  |  |
Accrued royalties |  | 7,100 |  |  |
SMA License Agreement | SMA Foundation | Maximum |  |  |  |  |
Other Commitments |  |  |  |  |
Potential royalty payments due on net product sales |  | 52,500 |  |  |
Agilis |  |  |  |  |
Other Commitments |  |  |  |  |
Development milestone payments which the entity is obligated to pay | $ 40,000 | 40,000 |  |  |
Potential developmental and regulatory milestones |  | 331,000 |  |  |
Potential sales milestones |  | 150,000 |  |  |
Milestone obligation payments made |  |  |  | $ 50,000 |
Development milestone obligation payments made |  | $ 2,400 |  |  |
Agilis | Minimum |  |  |  |  |
Other Commitments |  |  |  |  |
Product sales (as a percent) |  | 2.00% |  |  |
Agilis | Maximum |  |  |  |  |
Other Commitments |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 60,000 |  |  |
Priority review voucher amount |  | 535,000 |  |  |
Potential sales milestones |  | $ 150,000 |  |  |
Product sales (as a percent) |  | 6.00% |  |  |
Development milestone payment obligations, net of cancellation and forfeiture |  | $ 20,000 |  |  |
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture |  | 361,000 |  |  |
Agilis | Rights Exchange Agreement |  |  |  |  |
Other Commitments |  |  |  |  |
Contingent liability cancellation and forfeiture of potential milestone payments | 174,000 |  |  |  |
Development milestone payment obligations, cancellation and forfeiture | 37,600 |  |  |  |
Contingent liability, cancellation and forfeiture | $ 211,600 |  |  |  |
BioElectron | Maximum |  |  |  |  |
Other Commitments |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | 200,000 |  |  |
Marathon | Agilis Merger Agreement |  |  |  |  |
Other Commitments |  |  |  |  |
Milestone obligation payments made |  | 50,000 |  |  |
Net product revenue | Wellcome Trust | Maximum |  |  |  |  |
Other Commitments |  |  |  |  |
Development milestone payments which the entity is obligated to pay |  | $ 14,500 |  |  |

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