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Intangible assets and goodwill - (Tables) | 3 Months Ended
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Mar. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract] |
Schedule of definite lived intangible assets | Definite lived intangible assets consisted of the following at March 31, 2023 and December 31, 2022:
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Reclass from | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | Indefinite Lived to | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | March 31,
intangibles assets, gross |  | ​ | 2022 |  | ​ | Additions |  | ​ | Definite Lived |  | ​ | Impairment |  | ​ | translation |  | ​ | 2023
Emflaza | ​ | $ | 420,253 | ​ | $ | 17,515 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | $ | 437,768
Waylivra | ​ | ​ | 9,316 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 170 | ​ | ​ | 9,486
Tegsedi | ​ | ​ | 7,109 | ​ | ​ | 2,001 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 131 | ​ | ​ | 9,241
Upstaza | ​ | ​ | 89,550 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 89,550
Total definite lived intangibles, gross | ​ | $ | 526,228 | ​ | $ | 19,516 | ​ | $ | — | ​ | $ | — | ​ | $ | 301 | ​ | $ | 546,045
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Definite lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | March 31,
intangibles assets, accumulated amortization |  | ​ | 2022 |  | ​ | Amortization |  | ​ | translation |  | ​ | 2023
Emflaza | ​ | $ | (266,023) | ​ | $ | (36,996) | ​ | $ | — | ​ | $ | (303,019)
Waylivra | ​ | ​ | (2,751) | ​ | ​ | (261) | ​ | ​ | (52) | ​ | ​ | (3,064)
Tegsedi | ​ | ​ | (1,709) | ​ | ​ | (292) | ​ | ​ | (36) | ​ | ​ | (2,037)
Upstaza | ​ | ​ | (3,420) | ​ | ​ | (1,866) | ​ | ​ | — | ​ | ​ | (5,286)
Total definite lived intangibles, accumulated amortization | ​ | $ | (273,903) | ​ | $ | (39,415) | ​ | $ | (88) | ​ | $ | (313,406)
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total definite lived intangibles, net | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | $ | 232,639
​
Schedule of estimated future amortization of intangible assets | ​
​ | ​ | ​ | ​
​ |  | As of March 31, 2023
2023 | ​ | $ | 118,266
2024 | ​ |  | 33,462
2025 | ​ |  | 9,702
2026 | ​ |  | 9,702
2027 and thereafter | ​ |  | 61,507
Total | ​ | $ | 232,639
​
Schedule of indefinite lived intangible assets | Indefinite lived intangible assets consisted of the following at March 31, 2023 and December 31, 2022:
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | Ending Balance at | ​ | ​ | ​ | ​ | ​ | Reclass from | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | Ending Balance at
Indefinite lived | ​ | ​ | December 31, | ​ | ​ | ​ | ​ | ​ | Indefinite Lived to | ​ | ​ | ​ | ​ | ​ | currency | ​ | ​ | March 31,
intangibles assets |  | ​ | 2022 |  | ​ | Additions |  | ​ | Definite Lived |  | ​ | Impairment |  | ​ | translation |  | ​ | 2023
Upstaza | ​ | $ | 235,766 | ​ | $ | — | ​ | $ | — | ​ | $ | — | ​ | $ | — | ​ | $ | 235,766
PTC-FA | ​ | ​ | 112,500 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 112,500
PTC-AS | ​ | ​ | 105,300 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 105,300
Total indefinite lived intangibles | ​ | $ | 453,566 | ​ | $ | — | ​ | $ | — | ​ | $ | — | ​ | $ | — | ​ | $ | 453,566
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total intangible assets, net | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | $ | 686,205
​

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