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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022
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Payables and Accruals [Abstract] |  |
Employee compensation, benefits, and related accruals | $ 36,417 | $ 62,669
Income tax payable | 5,730 | 4,712
Consulting and contracted research | 22,547 | 38,882
Professional fees | 4,216 | 3,093
Sales allowance | 68,136 | 63,787
Sales rebates | 94,296 | 67,355
Royalties | 32,694 | 40,546
Accounts payable | 26,311 | 27,268
Milestone payable | 32,500 |
Other | 9,244 | 12,054
Accounts payable and accrued expenses | $ 332,091 | $ 320,366

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