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Intangible assets and goodwill - (Tables)
3 Months Ended
Mar. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract]  
Schedule of definite lived intangible assets

Definite lived intangible assets consisted of the following at March 31, 2023 and December 31, 2022:

Ending Balance at

Reclass from

Foreign

Ending Balance at

Definite lived

December 31,

Indefinite Lived to

currency

March 31,

intangibles assets, gross

    

2022

    

Additions

    

Definite Lived

    

Impairment

    

translation

    

2023

Emflaza

$

420,253

$

17,515

$

437,768

Waylivra

9,316

170

9,486

Tegsedi

7,109

2,001

131

9,241

Upstaza

89,550

89,550

Total definite lived intangibles, gross

$

526,228

$

19,516

$

$

$

301

$

546,045

Ending Balance at

Foreign

Ending Balance at

Definite lived

December 31,

currency

March 31,

intangibles assets, accumulated amortization

    

2022

    

Amortization

    

translation

    

2023

Emflaza

$

(266,023)

$

(36,996)

$

$

(303,019)

Waylivra

(2,751)

(261)

(52)

(3,064)

Tegsedi

(1,709)

(292)

(36)

(2,037)

Upstaza

(3,420)

(1,866)

(5,286)

Total definite lived intangibles, accumulated amortization

$

(273,903)

$

(39,415)

$

(88)

$

(313,406)

Total definite lived intangibles, net

$

232,639

Schedule of estimated future amortization of intangible assets

    

As of March 31, 2023

2023

$

118,266

2024

 

33,462

2025

 

9,702

2026

 

9,702

2027 and thereafter

 

61,507

Total

$

232,639

Schedule of indefinite lived intangible assets

Indefinite lived intangible assets consisted of the following at March 31, 2023 and December 31, 2022:

Ending Balance at

Reclass from

Foreign

Ending Balance at

Indefinite lived

December 31,

Indefinite Lived to

currency

March 31,

intangibles assets

    

2022

    

Additions

    

Definite Lived

    

Impairment

    

translation

    

2023

Upstaza

$

235,766

$

$

$

$

$

235,766

PTC-FA

112,500

112,500

PTC-AS

105,300

105,300

Total indefinite lived intangibles

$

453,566

$

$

$

$

$

453,566

Total intangible assets, net

$

686,205