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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Collaboration and royalty revenue
Revenue	$ 220,382	$ 148,735
Collaboration and grant revenue
Collaboration and royalty revenue
Revenue	6	7
Royalty revenue
Collaboration and royalty revenue
Revenue	30,831	18,896
SMA License Agreement | Royalty revenue
Collaboration and royalty revenue
Revenue	$ 30,800	$ 18,900

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