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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Revenues:    
Revenue $ 220,382 $ 148,735
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible assets 14,144 10,135
Amortization of intangible assets 39,415 23,473
Research and development 195,124 140,078
Selling, general and administrative 86,914 73,271
Change in the fair value of deferred and contingent consideration 2,400 (11,700)
Total operating expenses 337,997 235,257
Loss from operations (117,615) (86,522)
Interest expense, net (27,331) (23,514)
Other income (expense), net 9,956 (11,855)
Loss before income tax expense (134,990) (121,891)
Income tax expense (3,969) (4,835)
Net loss attributable to common stockholders $ (138,959) $ (126,726)
Weighted-average shares outstanding:    
Basic 73,729,284 71,215,105
Diluted 73,729,284 71,215,105
Net loss per share-basic and diluted (in dollars per share)    
Basic $ (1.88) $ (1.78)
Diluted $ (1.88) $ (1.78)
Net product revenue    
Revenues:    
Revenue $ 187,557 $ 129,832
Collaboration revenue    
Revenues:    
Revenue 6 7
Royalty revenue    
Revenues:    
Revenue 30,831 18,896
Manufacturing revenue    
Revenues:    
Revenue $ 1,988 $ 0