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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Jun. 08, 2022
Dec. 31, 2022
Dec. 31, 2020
Jun. 30, 2016
Mar. 31, 2023
Mar. 31, 2022
Apr. 30, 2022
Jun. 30, 2021
May 31, 2021
Jan. 31, 2020
Stock option plan                    
Share-based compensation expense         $ 28,815 $ 26,589        
Unrecognized compensation cost         $ 238,400          
Weighted average remaining service period for recognition of unrecognized compensation cost         2 years 4 months 20 days          
Stock option                    
Stock option plan                    
Granted (in shares)         863,410          
Forfeited (in shares)         53,716          
Expected dividend yield (as a percent)         0.00%          
Weighted average grant date fair value (in dollars per share)         $ 21.18          
Restricted stock units                    
Stock option plan                    
Granted (in shares)         1,861,235          
Employee Stock Purchase Plan                    
Stock option plan                    
Number of shares authorized (in shares)               2,000,000 1,000,000  
Award requisite service period       6 months            
Purchase price of common stock, percent       85.00%            
Employee stock purchase plan, voting percentage limit       5.00%            
Share-based compensation expense         $ 700          
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock                    
Stock option plan                    
Number of shares available for issuance         0          
Amended 2013 LTIP                    
Stock option plan                    
Number of shares available for issuance         6,598,348          
Number of additional shares authorized (in shares) 8,475,000                  
Amended 2013 LTIP | Maximum                    
Stock option plan                    
Number of shares authorized (in shares) 16,724,212                  
2020 Inducement Stock Incentive Plan                    
Stock option plan                    
Vesting period         4 years          
2020 Inducement Stock Incentive Plan | Maximum                    
Stock option plan                    
Expiration period         10 years          
2020 Inducement Stock Incentive Plan | Common stock                    
Stock option plan                    
Number of shares available for issuance         1,699,326          
Number of additional shares authorized (in shares)   1,700,000 1,000,000              
2020 Inducement Stock Incentive Plan | Common stock | Maximum                    
Stock option plan                    
Number of shares authorized (in shares)             1,300,000     1,000,000
2020 Inducement Stock Incentive Plan | Stock option                    
Stock option plan                    
Stockholder's specified ownership percentage         10.00%          
Inducement grants for non-statutory stock options (in shares)         98,050          
2020 Inducement Stock Incentive Plan | Stock option | Minimum                    
Stock option plan                    
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date         100.00%          
2020 Inducement Stock Incentive Plan | Stock option | Maximum                    
Stock option plan                    
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date         110.00%          
2020 Inducement Stock Incentive Plan | Restricted stock units                    
Stock option plan                    
Granted (in shares)         42,755