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Revenue recognition - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Nov. 30, 2011
Revenue recognition
Remaining potential milestones that can be achieved	$ 250,000
Revenue	220,382	$ 148,735
Collaboration revenue
Revenue recognition
Revenue	6	7
Royalty revenue
Revenue recognition
Revenue	30,831	18,896
SMA License Agreement | Royalty revenue
Revenue recognition
Revenue	30,800	$ 18,900
Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	0
Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	$ 250,000
Maximum | Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved			$ 135,000
Maximum | Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved			$ 325,000

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