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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash flows from operating activities    
Net loss $ (138,959) $ (126,726)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 42,825 26,314
Non-cash operating lease expense 2,942 1,908
Non-cash royalty revenue related to sale of future royalties (13,237) (8,113)
Non-cash interest expense on liability related to sale of future royalties 18,902 18,874
Change in valuation of deferred and contingent consideration 2,400 (11,700)
Unrealized loss (gain) on ClearPoint Equity Investments 39 1,049
Unrealized (gain) loss on ClearPoint convertible debt security (59) 1,542
Unrealized (gain) loss on marketable securities - equity investments (2,166) 6,477
Disposal of asset   79
Amortization of (discounts) premiums on investments, net (85) 887
Deferred income taxes (4)  
Amortization of debt issuance costs 438 464
Share-based compensation expense 28,815 26,589
Unrealized foreign currency transaction (gains) losses, net (10,057) 2,135
Changes in operating assets and liabilities:    
Inventory, net (4,612) 350
Prepaid expenses and other current assets 57,611 25,118
Trade and royalty receivables, net (43,426) (28,372)
Deposits and other assets 743 (510)
Accounts payable and accrued expenses 33,524 (30,680)
Other liabilities (3,988) (3,089)
Deferred revenue (1,137)  
Net cash used in operating activities (29,491) (97,404)
Cash flows from investing activities    
Purchases of fixed assets (10,270) (9,312)
Purchases of marketable securities - available for sale   (39,035)
Sale and redemption of marketable securities- available for sale 12,500 167,101
Sale and redemption of marketable securities - equity investments 2,196 2,423
Acquisition of product rights and licenses (33,397) (72,134)
Net cash (used in) provided by investing activities (28,971) 49,043
Cash flows from financing activities    
Proceeds from exercise of options 5,655 2,444
Debt issuance costs related to secured term loan (182)  
Payment of finance lease principal (1,379) (1,276)
Net cash provided by financing activities 4,094 1,168
Effect of exchange rate changes on cash (7,963) 1,653
Net decrease in cash and cash equivalents (62,331) (45,540)
Cash and cash equivalents, and restricted cash beginning of period 295,925 197,218
Cash and cash equivalents, and restricted cash end of period 233,594 151,678
Supplemental disclosure of cash information    
Cash paid for interest 12,956 6,130
Cash paid for income taxes 2,215 1,987
Supplemental disclosure of non-cash investing and financing activity    
Unrealized gain (loss) on marketable securities, net of tax 54 (2,913)
Right-of-use assets obtained in exchange for operating lease obligations   587
Acquisition of product rights and licenses 19,406 $ 12,589
Debt issuance costs related to senior secured term loan 45  
Capital expenditures unpaid at the end of period 28  
Milestone payable $ 32,500