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Stock award plan - (Tables)

6 Months Ended

Jun. 30, 2023

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2022		11,502,417	​	$	43.33				​	​
Granted		992,674	​	$	41.39				​	​
Exercised		(692,612)	​	$	29.37				​	​
Forfeited/Cancelled		(127,988)	​	$	49.84				​	​
Outstanding at June 30, 2023		11,674,491	​	$	43.92		6.27	years	​	$	44,184
Vested or Expected to vest at June 30, 2023		3,112,415	​	$	47.05		8.34	years	​	$	3,578
Exercisable at June 30, 2023		8,259,224	​	$	42.71		5.40	years	​	$	40,195

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

​

​	​	​
​		Six months ended
​		June 30, 2023
Risk-free interest rate		3.54% - 3.88%
Expected volatility		53% - 54%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2022	​	2,516,336	​	$	45.67
Granted		1,943,288	​	​	40.00
Vested		(751,448)	​	​	46.46
Forfeited		(91,237)	​	​	42.49
Unvested at June 30, 2023		3,616,939	​	$	42.54

Schedule of share-based compensation expense recorded in the statement of operations

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Three Months Ended June 30,

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Six Months Ended June 30,

​

​

2023

2022

2023

2022

​

Research and development

​

$

15,529

​

$

13,798

​

$

30,842

​

$

26,832

​

Selling, general and administrative

​

13,842

​

13,932

​

27,344

​

27,487

​

Total

​

$

29,371

​

$

27,730

​

$

58,186

​

$

54,319

​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
-Subparagraph (c)
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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