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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Dec. 22, 2017
May 31, 2023
USD ($)
Jun. 30, 2022
USD ($)
Jul. 31, 2020
USD ($)
Jun. 30, 2023
USD ($)
segment
country
Jun. 30, 2022
USD ($)
country
segment
Jun. 30, 2023
USD ($)
segment
country
Jun. 30, 2022
USD ($)
segment
country
Dec. 31, 2019
USD ($)
Mar. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Number of operating segments | segment         1 1 1 1        
Allowance for credit loss     $ 0   $ 0 $ 0 $ 0 $ 0        
Increase in allowance for credit losses         0 0 0 0        
Allowance for doubtful accounts receivable         600   600       $ 300  
Revenue         213,808 165,526 434,190 314,262        
Cash consideration received from Royalty Purchase Agreement       $ 650,000                
Income taxes                        
Federal income tax statutory rate 21.00%                      
Federal income tax provision - IRC Section 174 R&D Expenses             1,500          
State income tax provision - IRC Section 174 R&D Expenses             10,500          
Deferred tax benefit   $ 50,900         50,907          
Impairment of indefinite-lived intangibles excluding goodwill         217,800   217,800          
PTC-FA and PTC-AS                        
Income taxes                        
Impairment of indefinite-lived intangibles excluding goodwill         217,800   217,800          
Indefinite-lived intangible assets                        
Income taxes                        
Impairment of indefinite-lived intangibles excluding goodwill             217,800          
Indefinite-lived intangible assets | PTC-FA and PTC-AS                        
Income taxes                        
Impairment of indefinite-lived intangibles excluding goodwill         217,800   217,800          
Agilis                        
Income taxes                        
Deferred tax liability                       $ 122,000
Deposits and other assets                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Bank guarantee         $ 500   $ 500          
Blackstone Credit Agreement                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Credit agreement reserve                   $ 50,000    
Hopewell Campus                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Period after which letter of credit may be reduced if lease is not in default                 5 years      
Hopewell Campus | Minimum                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Term for letter of credit (in years)                 5 years      
Hopewell Campus | Deposits and other assets                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Letters of credit                 $ 7,500      
Hopewell Campus | Fifth Anniversary                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Letters of credit                 $ 3,800      
Warren Premises                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Period after which letter of credit may be reduced if lease is not in default     5 years                  
Warren Premises | Deposits and other assets                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Letters of credit     $ 8,100     8,100   8,100        
Warren Premises | Fifth Anniversary                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Letters of credit     $ 4,100     $ 4,100   $ 4,100        
Net product revenue | Geographic concentration risk                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Number of countries exceeding 10% of net product sales | country         3 2 3 3        
Percentage of net product sales threshold         10.00% 10.00% 10.00% 10.00%        
Net product revenue | Geographic concentration risk | Russia                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         $ 19,100 $ 23,600 $ 63,700 $ 28,900        
Net product revenue | Geographic concentration risk | Brazil                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         23,100   48,900 32,500        
Net product revenue | Geographic concentration risk | United States                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         65,700 56,800 120,300 105,400        
Net product revenue                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         174,592 143,701 362,149 273,534        
Net product revenue | Non-US                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         108,900 86,900 241,800 168,100        
Emflaza | United States                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         65,700 56,800 120,300 105,400        
Translarna | Non-US                        
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                        
Revenue         $ 96,500 $ 77,000 $ 211,600 $ 156,200