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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2023
Jun. 30, 2022
Jun. 30, 2023
Jun. 30, 2022
Revenues:        
Revenue $ 213,808 $ 165,526 $ 434,190 $ 314,262
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 12,731 9,639 26,875 19,774
Amortization of intangible assets 47,397 26,294 86,812 49,767
Research and development 185,874 157,263 380,998 297,341
Selling, general and administrative 88,449 79,892 175,363 153,162
Change in the fair value of contingent consideration (128,900) (15,200) (126,500) (26,900)
Intangible asset impairment 217,800   217,800  
Total operating expenses 423,351 257,888 761,348 493,144
Loss from operations (209,543) (92,362) (327,158) (178,882)
Interest expense, net (29,415) (21,976) (56,745) (45,490)
Other income (expense), net 1,479 (34,357) 11,434 (46,214)
Loss before income tax benefit (expense) (237,479) (148,695) (372,469) (270,586)
Income tax benefit (expense) 38,596 (3,392) 34,627 (8,227)
Net loss attributable to common stockholders $ (198,883) $ (152,087) $ (337,842) $ (278,813)
Weighted-average shares outstanding:        
Basic 74,730,433 71,372,940 74,232,624 71,294,458
Diluted 74,730,433 71,372,940 74,232,624 71,294,458
Net loss per share-basic and diluted (in dollars per share)        
Basic $ (2.66) $ (2.13) $ (4.55) $ (3.91)
Diluted $ (2.66) $ (2.13) $ (4.55) $ (3.91)
Net product revenue        
Revenues:        
Revenue $ 174,592 $ 143,701 $ 362,149 $ 273,534
Collaboration revenue        
Revenues:        
Revenue     6 7
Royalty revenue        
Revenues:        
Revenue 36,853 21,825 67,684 40,721
Manufacturing revenue        
Revenues:        
Revenue $ 2,363 $ 0 $ 4,351 $ 0