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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - USD ($) $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2023	Jun. 30, 2022
PTC-FA and PTC-AS
Changes in the fair value of warrant liability and SARs liability
Change in fair value	$ 129,800
Ending Balance	0	$ 0
Upstaza
Changes in the fair value of warrant liability and SARs liability
Ending Balance	37,500	37,500
Development and Regulatory Milestones | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance		82,500	$ 139,300
Additions		0	0
Change in fair value		(56,100)	(10,600)
Reclass to accounts payable and accrued expenses			(50,000)
Rights Exchange settlement		0	0
Ending Balance	26,400	26,400	78,700
Net Sales Milestones and Royalties | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance		81,500	100,600
Additions		0	0
Change in fair value		(70,400)	(16,300)
Reclass to accounts payable and accrued expenses			0
Rights Exchange settlement		0	0
Ending Balance	$ 11,100	$ 11,100	$ 84,300

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+ References

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- Definition

Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
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-Publisher FASB
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- Definition

Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

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-SubTopic 10
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- Definition

Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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