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Accounts payable and accrued expenses - Narrative (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Payables and Accruals [Abstract]
Employee compensation, benefits, and related accruals	$ 48,707	$ 62,669
Income tax payable	11,149	4,712
Consulting and contracted research	28,522	38,882
Professional fees	3,750	3,093
Sales allowance	71,979	63,787
Sales rebates	108,376	67,355
Royalties	51,720	40,546
Accounts payable	25,741	27,268
Other	8,618	12,054
Accounts payable and accrued expenses	$ 358,562	$ 320,366

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Sales Allowance And Other Related Costs

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

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Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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