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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Stock option plan
Share-based compensation expense	$ 29,371	$ 27,730	$ 58,186	$ 54,319
Unrecognized compensation cost	212,700		$ 212,700
Weighted average remaining service period for recognition of unrecognized compensation cost			2 years 3 months 18 days
Research and development
Stock option plan
Share-based compensation expense	15,529	13,798	$ 30,842	26,832
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 13,842	$ 13,932	$ 27,344	$ 27,487

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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