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Consolidated Statements of Stockholders' (Deficit) Equity - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Total
Balance (in shares) at Dec. 31, 2021 70,828,226        
Balance at the beginning of the period at Dec. 31, 2021 $ 71 $ 2,123,606 $ (24,282) $ (2,097,957) $ 1,438
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 125,020        
Exercise of options   3,198     3,198
Restricted stock vesting and issuance (in shares) 461,380        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 91,263        
Issuance of common stock in connection with an employee stock purchase plan   3,107     3,107
Share-based compensation expense   54,319     54,319
Net Income (Loss)       (278,813) (278,813)
Comprehensive income (loss)     34,533   34,533
Balance (in shares) at Jun. 30, 2022 71,505,889        
Balance at the end of the period at Jun. 30, 2022 $ 71 2,184,230 10,251 (2,376,770) (182,218)
Balance (in shares) at Mar. 31, 2022 71,337,041        
Balance at the beginning of the period at Mar. 31, 2022 $ 71 2,152,639 (18,608) (2,224,683) (90,581)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 27,832        
Exercise of options   754     754
Restricted stock vesting and issuance (in shares) 49,753        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 91,263        
Issuance of common stock in connection with an employee stock purchase plan   3,107     3,107
Share-based compensation expense   27,730     27,730
Net Income (Loss)       (152,087) (152,087)
Comprehensive income (loss)     28,859   28,859
Balance (in shares) at Jun. 30, 2022 71,505,889        
Balance at the end of the period at Jun. 30, 2022 $ 71 2,184,230 10,251 (2,376,770) (182,218)
Balance (in shares) at Dec. 31, 2022 73,104,692        
Balance at the beginning of the period at Dec. 31, 2022 $ 72 2,305,020 4,796 (2,656,974) (347,086)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 692,612        
Exercise of options $ 1 20,324     20,325
Restricted stock vesting and issuance (in shares) 746,163        
Restricted stock vesting and issuance, net $ 1       1
Issuance of common stock in connection with an employee stock purchase plan (in shares) 117,304        
Issuance of common stock in connection with an employee stock purchase plan   3,805     3,805
Issuance of common stock in connection with a milestone payable (in shares) 657,462        
Issuance of common stock in connection with a milestone payable $ 1 29,569     29,570
Share-based compensation expense   58,186     58,186
Net Income (Loss)       (337,842) (337,842)
Comprehensive income (loss)     (6,227)   (6,227)
Balance (in shares) at Jun. 30, 2023 75,318,233        
Balance at the end of the period at Jun. 30, 2023 $ 75 2,416,904 (1,431) (2,994,816) (579,268)
Balance (in shares) at Mar. 31, 2023 74,012,034        
Balance at the beginning of the period at Mar. 31, 2023 $ 73 2,339,886 (1,587) (2,795,933) (457,561)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 481,051        
Exercise of options $ 1 14,273     14,274
Restricted stock vesting and issuance (in shares) 50,382        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 117,304        
Issuance of common stock in connection with an employee stock purchase plan   3,805     3,805
Issuance of common stock in connection with a milestone payable (in shares) 657,462        
Issuance of common stock in connection with a milestone payable $ 1 29,569     29,570
Share-based compensation expense   29,371     29,371
Net Income (Loss)       (198,883) (198,883)
Comprehensive income (loss)     156   156
Balance (in shares) at Jun. 30, 2023 75,318,233        
Balance at the end of the period at Jun. 30, 2023 $ 75 $ 2,416,904 $ (1,431) $ (2,994,816) $ (579,268)