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Revenue recognition - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Nov. 30, 2011
Revenue recognition
Remaining potential milestones that can be achieved	$ 250,000		$ 250,000
Revenue	213,808	$ 165,526	434,190	$ 314,262
Collaboration revenue
Revenue recognition
Revenue			6	7
Royalty revenue
Revenue recognition
Revenue	36,853	21,825	67,684	40,721
SMA License Agreement | Collaboration revenue
Revenue recognition
Revenue	0	0
SMA License Agreement | Royalty revenue
Revenue recognition
Revenue	36,900	$ 21,800	67,700	$ 40,700
Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	0		0
Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	$ 250,000		$ 250,000
Maximum | Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved					$ 135,000
Maximum | Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved					$ 325,000

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