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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - USD ($) $ in Thousands | 9 Months Ended
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Sep. 30, 2023 | Sep. 30, 2022
PTC-FA and PTC-AS |  |
Changes in the fair value of warrant liability and SARs liability |  |
Change in fair value | $ 129,800 |
Ending Balance | 0 |
Upstaza |  |
Changes in the fair value of warrant liability and SARs liability |  |
Ending Balance | 39,000 |
Development and Regulatory Milestones | Commitments |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | 82,500 | $ 139,300
Additions | 0 | 0
Change in fair value | (56,100) | (10,800)
Reclass to accounts payable and accrued expenses |  | (50,000)
Rights Exchange settlement | 0 | 0
Ending Balance | 26,400 | 78,500
Net Sales Milestones and Royalties | Commitments |  |
Changes in the fair value of warrant liability and SARs liability |  |
Beginning Balance | 81,500 | 100,600
Additions | 0 | 0
Change in fair value | (68,900) | (21,400)
Reclass to accounts payable and accrued expenses |  | 0
Rights Exchange settlement | 0 | 0
Ending Balance | $ 12,600 | $ 79,200

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- Definition A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period. + References No definition available. + Details
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- Definition Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 820 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(3) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 + Details
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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 820 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 + Details
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