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v3.23.3

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
Cash flows from operating activities |  |
Net Income (Loss) | $ (470,812) | $ (388,128)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 155,885 | 89,971
Non-cash operating lease expense | 8,156 | 7,505
Non-cash royalty revenue related to sale of future royalties | (50,599) | (31,617)
Non-cash interest expense on liability related to sale of future royalties | 56,031 | 55,778
Intangible asset impairment | 217,800 |
Change in valuation of contingent consideration | (125,000) | (32,200)
Unrealized loss on ClearPoint Equity Investments | 3,107 | 1,113
Unrealized loss on ClearPoint convertible debt security | 4,594 | 2,392
Unrealized (gain) loss on marketable securities - equity investments | (5,484) | 11,319
Realized loss for the sale of Clearpoint Equity Investment | 782 |
Non-cash stock consideration, milestone payment | 29,570 |
Disposal of asset | 135 | 81
Amortization of (discounts) premiums on investments, net | (89) | 1,792
Deferred income taxes | (50,909) |
Amortization of debt issuance costs | 1,574 | 1,316
Share-based compensation expense | 85,128 | 82,989
Unrealized foreign currency transaction losses, net | 3,394 | 71,246
Changes in operating assets and liabilities: |  |
Inventory, net | (14,121) | (768)
Prepaid expenses and other current assets | 59,467 | (35,615)
Trade and royalty receivables, net | (9,887) | (24,773)
Deposits and other assets | 4,597 | (3,752)
Accounts payable and accrued expenses | 40,434 | 1,568
Other liabilities | (1,756) | (908)
Deferred revenue | (127) |
Net cash used in operating activities | (58,130) | (190,691)
Cash flows from investing activities |  |
Purchases of fixed assets | (22,872) | (23,394)
Purchases of marketable securities - available for sale |  | (40,429)
Purchases of marketable securities - equity investments | (26,378) | (22,787)
Sale and redemption of marketable securities- available for sale | 21,544 | 341,990
Sale and redemption of marketable securities - equity investments | 12,078 | 104,431
Sale and redemption of ClearPoint Equity Investments | 2,594 |
Acquisition of product rights and licenses | (69,285) | (102,069)
Net cash (used in) provided by investing activities | (82,319) | 257,742
Cash flows from financing activities |  |
Proceeds from exercise of options | 23,771 | 13,203
Debt issuance costs related to secured term loan | (282) |
Repayment of Convertible Notes |  | (150,000)
Proceeds from employee stock purchase plan | 3,805 | 3,107
Payment of finance lease principal | (1,379) | (1,276)
Net cash provided by (used in) financing activities | 25,915 | (134,966)
Effect of exchange rate changes on cash | 19 | (8,792)
Net decrease in cash and cash equivalents | (114,515) | (76,707)
Cash and cash equivalents, and restricted cash beginning of period | 295,925 | 197,218
Cash and cash equivalents, and restricted cash end of period | 181,410 | 120,511
Supplemental disclosure of cash information |  |
Cash paid for interest | 34,020 | 12,679
Cash paid for income taxes | 13,631 | 4,029
Supplemental disclosure of non-cash investing and financing activity |  |
Unrealized gain (loss) on marketable securities, net of tax | 470 | (2,333)
Right-of-use assets obtained in exchange for operating lease obligations |  | 35,294
Acquisition of product rights and licenses | 44,963 | 27,828
Milestone payable | $ 2,500 | $ 50,000

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