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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Revenues:        
Revenue $ 196,576 $ 217,127 $ 630,766 $ 531,389
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 9,493 14,011 36,368 33,785
Amortization of intangible assets 58,649 31,023 145,461 80,790
Research and development 164,212 165,462 545,210 462,802
Selling, general and administrative 80,886 80,118 256,249 233,280
Change in the fair value of contingent consideration 1,500 (5,300) (125,000) (32,200)
Intangible asset impairment     217,800  
Total operating expenses 314,740 285,314 1,076,088 778,457
Loss from operations (118,164) (68,187) (445,322) (247,068)
Interest expense, net (28,160) (20,880) (84,905) (66,371)
Other expense, net (20,266) (38,141) (8,832) (84,355)
Loss before income tax benefit (166,590) (127,208) (539,059) (397,794)
Income tax benefit 33,620 17,893 68,247 9,666
Net loss attributable to common stockholders $ (132,970) $ (109,315) $ (470,812) $ (388,128)
Weighted-average shares outstanding:        
Basic 75,377,997 71,654,671 74,618,611 71,415,849
Diluted 75,377,997 71,654,671 74,618,611 71,415,849
Net loss per share-basic and diluted (in dollars per share)        
Basic $ (1.76) $ (1.53) $ (6.31) $ (5.43)
Diluted $ (1.76) $ (1.53) $ (6.31) $ (5.43)
Net product revenue        
Revenues:        
Revenue $ 144,038 $ 134,186 $ 506,187 $ 407,720
Collaboration revenue        
Revenues:        
Revenue 0 50,017 6 50,024
Royalty revenue        
Revenues:        
Revenue 50,173 32,924 117,857 73,645
Manufacturing revenue        
Revenues:        
Revenue $ 2,365 $ 0 $ 6,716 $ 0