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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022
PTC-FA and PTC-AS
Changes in the fair value of warrant liability and SARs liability
Change in fair value	$ 129,800
Ending Balance	0
Upstaza
Changes in the fair value of warrant liability and SARs liability
Ending Balance	39,000
Development and Regulatory Milestones | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	82,500	$ 139,300
Additions	0	0
Change in fair value	(56,100)	(10,800)
Reclass to accounts payable and accrued expenses		(50,000)
Rights Exchange settlement	0	0
Ending Balance	26,400	78,500
Net Sales Milestones and Royalties | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	81,500	100,600
Additions	0	0
Change in fair value	(68,900)	(21,400)
Reclass to accounts payable and accrued expenses		0
Rights Exchange settlement	0	0
Ending Balance	$ 12,600	$ 79,200

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+ References

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- Definition

Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)(3)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482106/820-10-50-2

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- Definition

Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

+ References

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-Topic 820
-SubTopic 10
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- Definition

Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

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Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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