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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis - Commitments $ in Thousands	Sep. 30, 2023 USD ($)	Dec. 31, 2022 USD ($)	Sep. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	$ 0	$ 0
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 31,000	$ 331,000
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.85	0.25
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.92	0.92
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.90
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.069	0.062
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.076	0.083
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.071
Development and Regulatory Milestones | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value	$ 26,400	$ 82,500	$ 78,500	$ 139,300
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0	0
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 50,000	$ 150,000
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.85	0.25
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	1	1
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.93
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.02
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.06
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.12	0.115
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.120
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3)
Fair Value Valuation Inputs
Fair value	$ 12,600	$ 81,500	$ 79,200	$ 100,600

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Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)
-SubTopic 10
-Topic 820
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482106/820-10-50-2

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