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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 08, 2022
Dec. 31, 2022
Dec. 31, 2020
Jun. 30, 2016
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Apr. 30, 2022
Jun. 30, 2021
May 31, 2021
Jan. 31, 2020
Stock option plan                        
Share-based compensation expense         $ 26,942 $ 28,670 $ 85,128 $ 82,989        
Unrecognized compensation cost         179,300   $ 179,300          
Weighted average remaining service period for recognition of unrecognized compensation cost             1 year 10 months 24 days          
Stock option                        
Stock option plan                        
Granted (in shares)             1,059,054          
Expected dividend yield (as a percent)             0.00%          
Weighted average grant date fair value (in dollars per share)             $ 21.83          
Restricted stock units                        
Stock option plan                        
Granted (in shares)             1,973,973          
Employee Stock Purchase Plan                        
Stock option plan                        
Number of shares authorized (in shares)                   2,000,000 1,000,000  
Award requisite service period       6 months                
Purchase price of common stock, percent       85.00%                
Employee stock purchase plan, voting percentage limit       5.00%                
Share-based compensation expense         $ 700   $ 2,000          
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock                        
Stock option plan                        
Number of shares available for issuance         0   0          
Amended 2013 LTIP                        
Stock option plan                        
Number of shares available for issuance         6,802,210   6,802,210          
Number of additional shares authorized (in shares) 8,475,000                      
Amended 2013 LTIP | Maximum                        
Stock option plan                        
Number of shares authorized (in shares) 16,724,212                      
2020 Inducement Stock Incentive Plan | Common stock                        
Stock option plan                        
Number of shares available for issuance         1,705,941   1,705,941          
Number of additional shares authorized (in shares)   1,700,000 1,000,000                  
2020 Inducement Stock Incentive Plan | Common stock | Maximum                        
Stock option plan                        
Number of shares authorized (in shares)                 1,300,000     1,000,000
2020 Inducement Stock Incentive Plan | Stock option                        
Stock option plan                        
Stockholder's specified ownership percentage         10.00%   10.00%          
Inducement grants for non-statutory stock options (in shares)             121,460          
Vesting period             4 years          
2020 Inducement Stock Incentive Plan | Stock option | Minimum                        
Stock option plan                        
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date         100.00%   100.00%          
2020 Inducement Stock Incentive Plan | Stock option | Maximum                        
Stock option plan                        
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date         110.00%   110.00%          
Expiration period             10 years          
2020 Inducement Stock Incentive Plan | Restricted stock units                        
Stock option plan                        
Granted (in shares)             83,210