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Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Stock option plan
Share-based compensation expense	$ 26,942	$ 28,670	$ 85,128	$ 82,989
Unrecognized compensation cost	179,300		$ 179,300
Weighted average remaining service period for recognition of unrecognized compensation cost			1 year 10 months 24 days
Research and development
Stock option plan
Share-based compensation expense	13,986	15,063	$ 44,828	41,896
Selling, general and administrative
Stock option plan
Share-based compensation expense	$ 12,956	$ 13,607	$ 40,300	$ 41,093

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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