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Consolidated Statements of Stockholders' (Deficit) Equity - USD ($)
$ in Thousands
Common stock
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Total
Balance (in shares) at Dec. 31, 2021 70,828,226        
Balance at the beginning of the period at Dec. 31, 2021 $ 71 $ 2,123,606 $ (24,282) $ (2,097,957) $ 1,438
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 456,399        
Exercise of options   13,203     13,203
Restricted stock vesting and issuance (in shares) 479,004        
Issuance of common stock in connection with an employee stock purchase plan (in shares) 91,263        
Issuance of common stock in connection with an employee stock purchase plan   3,107     3,107
Share-based compensation expense   82,989     82,989
Net Income (Loss)       (388,128) (388,128)
Comprehensive income     60,487   60,487
Balance (in shares) at Sep. 30, 2022 71,854,892        
Balance at the end of the period at Sep. 30, 2022 $ 71 2,222,905 36,205 (2,486,085) (226,904)
Balance (in shares) at Jun. 30, 2022 71,505,889        
Balance at the beginning of the period at Jun. 30, 2022 $ 71 2,184,230 10,251 (2,376,770) (182,218)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 331,379        
Exercise of options   10,005     10,005
Restricted stock vesting and issuance (in shares) 17,624        
Share-based compensation expense   28,670     28,670
Net Income (Loss)       (109,315) (109,315)
Comprehensive income     25,954   25,954
Balance (in shares) at Sep. 30, 2022 71,854,892        
Balance at the end of the period at Sep. 30, 2022 $ 71 2,222,905 36,205 (2,486,085) (226,904)
Balance (in shares) at Dec. 31, 2022 73,104,692        
Balance at the beginning of the period at Dec. 31, 2022 $ 72 2,305,020 4,796 (2,656,974) (347,086)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 806,407        
Exercise of options $ 1 23,770     23,771
Restricted stock vesting and issuance (in shares) 773,157        
Restricted stock vesting and issuance, net $ 1       1
Issuance of common stock in connection with an employee stock purchase plan (in shares) 117,304        
Issuance of common stock in connection with an employee stock purchase plan   3,805     3,805
Issuance of common stock in connection with a milestone payable (in shares) 657,462        
Issuance of common stock in connection with a milestone payable $ 1 29,569     29,570
Share-based compensation expense   85,128     85,128
Net Income (Loss)       (470,812) (470,812)
Comprehensive income     4,813   4,813
Balance (in shares) at Sep. 30, 2023 75,459,022        
Balance at the end of the period at Sep. 30, 2023 $ 75 2,447,292 9,609 (3,127,786) (670,810)
Balance (in shares) at Jun. 30, 2023 75,318,233        
Balance at the beginning of the period at Jun. 30, 2023 $ 75 2,416,904 (1,431) (2,994,816) (579,268)
Increase (Decrease) in Stockholders' Equity          
Exercise of options (in shares) 113,795        
Exercise of options   3,446     3,446
Restricted stock vesting and issuance (in shares) 26,994        
Share-based compensation expense   26,942     26,942
Net Income (Loss)       (132,970) (132,970)
Comprehensive income     11,040   11,040
Balance (in shares) at Sep. 30, 2023 75,459,022        
Balance at the end of the period at Sep. 30, 2023 $ 75 $ 2,447,292 $ 9,609 $ (3,127,786) $ (670,810)