Revenue recognition - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Nov. 30, 2011
Revenue recognition
Remaining potential milestones that can be achieved		$ 250,000		$ 250,000
Revenue		196,576	$ 217,127	630,766	$ 531,389
Collaboration revenue
Revenue recognition
Revenue		0	50,017	6	50,024
Royalty revenue
Revenue recognition
Revenue		50,173	32,924	117,857	73,645
SMA License Agreement \| Collaboration revenue
Revenue recognition
Revenue		0
SMA License Agreement \| Royalty revenue
Revenue recognition
Revenue		50,200	$ 32,900	117,900	$ 73,600
Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		0		0
Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved		$ 250,000		$ 250,000
Milestone payments due	$ 50,000
Net sales milestone threshold achieved	$ 750,000
Maximum \| Research And Development Event Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved						$ 135,000
Maximum \| Sales Milestones \| SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved						$ 325,000