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Fair value of financial instruments and investments - (Tables) | 12 Months Ended
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Dec. 31, 2023
Fair Value Disclosures [Abstract] |
Schedule of marketable securities | The table presented below is a summary of changes in the fair value for the Company’s marketable securities – equity investments, ClearPoint Equity Investments, and ClearPoint convertible debt security for the years ended December 31, 2023 and 2022:
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Ending | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Ending
​ | ​ | Balance at | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Currency | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Balance at
​ | ​ | December 31, | ​ | Unrealized | ​ | Realized | ​ | Unrealized | ​ | Investments | ​ | Redemptions/ | ​ | December 31,
​ |  | 2022 |  | Gain/(Loss) |  | Gain/(Loss) |  | Gain |  | Purchased |  | Sale |  | 2023
Marketable securities - equity investments | ​ | $ | 108,261 | ​ | ​ | 2,517 | ​ | ​ | 4,383 | ​ | ​ | 1,384 | ​ | ​ | 38,432 | ​ | ​ | (132,343) | ​ | $ | 22,634
ClearPoint Equity Investments | ​ | ​ | 10,965 | ​ | ​ | (1,515) | ​ | ​ | (782) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (2,594) | ​ | ​ | 6,074
ClearPoint Convertible Debt Security | ​ | ​ | 15,231 | ​ | ​ | (2,678) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 12,553
Total Fair Value | ​ | $ | 134,457 | ​ | $ | (1,676) | ​ | $ | 3,601 | ​ | $ | 1,384 | ​ | $ | 38,432 | ​ | $ | (134,937) | ​ | $ | 41,261
​ ​ ​ ​ ​ ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Ending | ​ | ​ | ​ | ​ | Foreign | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Ending
​ | ​ | Balance at | ​ | ​ | ​ | ​ | Currency | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Balance at
​ | ​ | December 31, | ​ | Unrealized | ​ | Unrealized | ​ | Investments | ​ | ​ | ​ | December 31,
​ |  | 2021 |  | Gain/(Loss) |  | Gain/(Loss) |  | Purchased |  | Redemptions |  | 2022
Marketable securities - equity investments | ​ | $ | 206,973 | ​ | ​ | (7,992) | ​ | ​ | (549) | ​ | ​ | 22,787 | ​ | ​ | (112,958) | ​ | $ | 108,261
ClearPoint Equity Investments | ​ | ​ | 14,525 | ​ | ​ | (3,560) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 10,965
ClearPoint Convertible Debt Security | ​ | ​ | 20,971 | ​ | ​ | (5,740) | ​ | ​ | — | ​ | ​ | — | ​ | ​ | — | ​ | ​ | 15,231
Total Fair Value | ​ | $ | 242,469 | ​ | $ | (17,292) | ​ | $ | (549) | ​ | $ | 22,787 | ​ | $ | (112,958) | ​ | $ | 134,457
Schedule of financial assets and liabilities that are required to be measured at fair value on a recurring basis | The following represents the fair value using the hierarchy described in Note 2 for the Company’s financial assets and liabilities that are required to be measured at fair value on a recurring basis as of December 31, 2023 and 2022: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2023
​ |  | ​ | ​ |  | Quoted prices |  | Significant |  | ​ | ​
​ | ​ | ​ | ​ |  | in active |  | other |  | Significant
​ | ​ | ​ | ​ |  | markets for |  | observable |  | unobservable
​ | ​ | ​ | ​ |  | identical assets |  | inputs |  | inputs
​ |  | Total |  | (level 1) |  | (level 2) |  | (level 3)
Marketable securities - available for sale | ​ | $ | 260,104 | ​ | $ | — | ​ | $ | 260,104 | ​ | $ | —
Marketable securities - equity investments | ​ | $ | 22,634 | ​ | $ | 22,634 | ​ | $ | — | ​ | $ | —
ClearPoint Equity Investments | ​ | $ | 6,074 | ​ | $ | 6,074 | ​ | $ | — | ​ | $ | —
ClearPoint convertible debt security | ​ | $ | 12,553 | ​ | $ | — | ​ | $ | 12,553 | ​ | $ | —
Contingent consideration payable- development and regulatory milestones | ​ | $ | 26,600 | ​ | $ | — | ​ | $ | — | ​ | $ | 26,600
Contingent consideration payable- net sales milestones | ​ | $ | 9,700 | ​ | $ | — | ​ | $ | — | ​ | $ | 9,700
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2022
​ |  | ​ | ​ |  | Quoted prices |  | Significant |  | ​ | ​
​ | ​ | ​ | ​ |  | in active |  | other |  | Significant
​ | ​ | ​ | ​ |  | markets for |  | observable |  | unobservable
​ | ​ | ​ | ​ |  | identical assets |  | inputs |  | inputs
​ |  | Total |  | (level 1) |  | (level 2) |  | (level 3)
Marketable securities - available for sale | ​ | $ | 22,610 | ​ | $ | — | ​ | $ | 22,610 | ​ | $ | —
Marketable securities - equity investments | ​ | $ | 108,261 | ​ | $ | 108,261 | ​ | $ | — | ​ | $ | —
ClearPoint Equity Investments | ​ | $ | 10,965 | ​ | $ | 10,965 | ​ | $ | — | ​ | $ | —
ClearPoint convertible debt security | ​ | $ | 15,231 | ​ | $ | — | ​ | $ | 15,231 | ​ | $ | —
Contingent consideration payable- development and regulatory milestones | ​ | $ | 82,500 | ​ | $ | — | ​ | $ | — | ​ | $ | 82,500
Contingent consideration payable- net sales milestones and royalties | ​ | $ | 81,500 | ​ | $ | — | ​ | $ | — | ​ | $ | 81,500
Summary of marketable securities accounted for as available-for-sale debt securities | The following is a summary of marketable securities accounted for as available for sale debt securities at December 31, 2023 and 2022: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2023
​ |  | Amortized |  | Gross Unrealized | ​ | ​ | ​
​ |  | Cost |  | Gains |  | Losses |  | Fair Value
Commercial paper | ​ | $ | 117,044 | ​ | $ | 128 | ​ | $ | (12) | ​ | $ | 117,160
Corporate debt securities | ​ | ​ | 1,650 | ​ | ​ | — | ​ | ​ | (2) | ​ | ​ | 1,648
Government Obligations | ​ | ​ | 141,084 | ​ | ​ | 212 | ​ | ​ | — | ​ | ​ | 141,296
Total | ​ | $ | 259,778 | ​ | $ | 340 | ​ | $ | (14) | ​ | $ | 260,104
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2022
​ |  | Amortized |  | Gross Unrealized | ​ | ​ | ​
​ |  | Cost |  | Gains |  | Losses |  | Fair Value
Commercial paper | ​ | $ | 12,419 | ​ | $ | 5 | ​ | $ | — | ​ | $ | 12,424
Corporate debt securities | ​ |  | 10,685 | ​ | ​ | — | ​ | ​ | (499) | ​ | ​ | 10,186
Total | ​ | $ | 23,104 | ​ | $ | 5 | ​ | $ | (499) | ​ | $ | 22,610
Summary of unrealized losses and fair values of available-for-sale debt securities in a continuous unrealized loss position | The unrealized losses and fair values of available for sale debt securities that have been in an unrealized loss position for a period of less than and greater than or equal to 12 months as of December 31, 2023 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2023
​ |  | Securities in an unrealized loss |  | Securities in an unrealized loss |  | ​ | ​ | ​ | ​ | ​
​ |  | position less than 12 months |  | position greater than or equal to 12 months | ​ | Total
​ |  | Unrealized losses |  | Fair Value |  | Unrealized losses |  | Fair Value |  | Unrealized losses |  | Fair Value
Commercial paper | ​ | $ | (12) | ​ | ​ | 44,446 | ​ | ​ | — | ​ | ​ | — | ​ | ​ | (12) | ​ | ​ | 44,446
Corporate debt securities | ​ | $ | — | ​ | ​ | — | ​ | ​ | (2) | ​ | ​ | 1,648 | ​ | ​ | (2) | ​ | $ | 1,648
Total | ​ | $ | (12) | ​ | $ | 44,446 | ​ | $ | (2) | ​ | $ | 1,648 | ​ | $ | (14) | ​ | $ | 46,094
​ The unrealized losses and fair values of available for sale debt securities that have been in an unrealized loss position for a period of less than and greater than or equal to 12 months as of December 31, 2022 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2022
​ |  | Securities in an unrealized loss |  | Securities in an unrealized loss |  | ​ | ​ | ​ | ​ | ​
​ |  | position less than 12 months |  | position greater than or equal to 12 months | ​ | Total
​ |  | Unrealized losses |  | Fair Value |  | Unrealized losses |  | Fair Value |  | Unrealized losses |  | Fair Value
Corporate debt securities | ​ | $ | — | ​ | ​ | — | ​ | ​ | (499) | ​ | ​ | 10,186 | ​ | ​ | (499) | ​ | $ | 10,186
Total | ​ | $ | — | ​ | $ | — | ​ | $ | (499) | ​ | $ | 10,186 | ​ | $ | (499) | ​ | $ | 10,186
Schedule of available-for-sale debt securities | Available for sale debt securities on the balance sheet at December 31, 2023 and 2022 mature as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2023
​ |  | Less Than |  | More Than
​ |  | 12 Months |  | 12 Months
Commercial paper | ​ | $ | 117,160 | ​ | $ | —
Corporate debt securities | ​ | ​ | 1,648 | ​ | ​ | —
Government obligations | ​ | ​ | 141,296 | ​ | ​ | —
Total | ​ | $ | 260,104 | ​ | $ | —
​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2022
​ |  | Less Than |  | More Than
​ |  | 12 Months |  | 12 Months
Commercial paper | ​ | $ | 12,424 | ​ | $ | —
Corporate debt securities | ​ |  | — | ​ |  | 10,186
Total | ​ | $ | 12,424 | ​ | $ | 10,186
Summary of changes in the fair value of the Company's Level 3 valuation for contingent consideration payable | The table presented below is a summary of changes in the fair value of the Company’s Level 3 valuation for the contingent consideration payables for the years ended December 31, 2023, and 2022:
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Contingent consideration payable- | ​ | Contingent consideration payable-
​ | ​ | development and regulatory | ​ | net sales milestones and royalties
​ |  | milestones - Agilis |  | - Agilis
Beginning balance as of December 31, 2021 | ​ | $ | 139,300 | ​ | $ | 100,600
Additions | ​ |  | — | ​ |  | —
Change in fair value | ​ |  | (6,800) | ​ |  | (19,100)
Payments | ​ | ​ | (50,000) | ​ |  | —
Ending balance as of December 31, 2022 | ​ | $ | 82,500 | ​ | $ | 81,500
Additions | ​ |  | — | ​ |  | —
Change in fair value | ​ |  | (55,900) | ​ | ​ | (71,800)
Payments | ​ |  | — | ​ |  | —
Ending balance as of December 31, 2023 | ​ | $ | 26,600 | ​ | $ | 9,700
Fair Value Measurement Inputs and Valuation Techniques | The following significant unobservable inputs were used in the valuation of the contingent consideration payables for the years ended December 31, 2023 and 2022: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2023
​ |  | Fair Value |  | Valuation Technique |  | Unobservable Input |  | Range
Contingent consideration payable- development and regulatory milestones | ​ | $26,600 |  | Probability-adjusted discounted cash flow |  | Potential development and regulatory milestones Probabilities of success Discount rates Projected years of payments | ​ | $0 - $31 million 85% - 92% 5.8% - 6.1% 2024 - 2026
Contingent considerable payable- net sales milestones and royalties | ​ | $9,700 |  | Option-pricing model with Monte Carlo simulation |  | Potential net sales milestones Probabilities of success Potential percentage of net sales for royalties Discount rate Projected years of payments | ​ | $0 - $50 million 85% - 100% 0% 11% 2026 - 2034
​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | December 31, 2022
​ |  | Fair Value |  | Valuation Technique |  | Unobservable Input |  | Range
Contingent consideration payable- development and regulatory milestones | ​ | $82,500 |  | Probability-adjusted discounted cash flow |  | Potential development and regulatory milestones Probabilities of success Discount rates Projected years of payments | ​ | $0 - $331 million 25% - 92% 6.2% - 8.3% 2023 - 2029
Contingent considerable payable- net sales milestones and royalties | ​ | $81,500 |  | Option-pricing model with Monte Carlo simulation |  | Potential net sales milestones Probabilities of success Potential percentage of net sales for royalties Discount rate Projected years of payments | ​ | $0 - $150 million 25% - 100% 2% - 6% 11.5% 2025 - 2041

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- Definition Tabular disclosure of the fair value measurement of liabilities using significant unobservable inputs (Level 3), a reconciliation of the beginning and ending balances, separately presenting changes attributable to the following: (1) total gains or losses for the period (realized and unrealized), segregating those gains or losses included in earnings (or changes in net assets), and gains or losses recognized in other comprehensive income (loss) and a description of where those gains or losses included in earnings (or changes in net assets) are reported in the statement of income (or activities); (2) purchases, sales, issues, and settlements (each type disclosed separately); and (3) transfers in and transfers out of Level 3 (for example, transfers due to changes in the observability of significant inputs) by class of liability. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c) -SubTopic 10 -Topic 820 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 3 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-3 + Details
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- Definition Tabular disclosure of marketable securities. This may consist of investments in certain debt and equity securities, short-term investments and other assets. + References No definition available. + Details
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- Definition Tabular disclosure of assets and liabilities, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 820 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 820 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 + Details
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