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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Deferred tax assets: |  |
Accrued expense | $ 25,400 | $ 2,124
Amortization | 137,808 | 52,532
Federal tax credits | 205,485 | 174,802
State tax credits | 9,817 | 9,787
Federal net operating losses | 60,270 | 69,957
State net operating losses | 18,680 | 10,316
Foreign net operating losses | 4,052 | 4,837
Capitalized research and development costs | 149,683 | 110,219
Share based compensation and other | 30,757 | 27,054
Liability for sale of future royalties | 190,659 | 185,589
Noncash interest expense | 9,410 | 30,160
Other comprehensive loss | (728) | (719)
Total gross deferred tax assets | 841,293 | 676,658
Less valuation allowance | (833,810) | (672,172)
Total deferred tax assets, net of valuation allowance | 7,483 | 4,486
Deferred tax liabilities: |  |
Depreciation | (7,483) | (4,486)
Indefinite lived intangible | (55,905) | (102,834)
Total gross deferred tax liabilities | (63,388) | (107,320)
Net deferred tax assets (liabilities) | $ (55,905) | $ (102,834)

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