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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2018
Operating loss carryforwards |  |  |  |
Taxable income before consideration of NOL | $ 102,500 |  |  |
State income tax benefit | 27,226 | $ (4,224) | $ (3,844) |
Deferred tax valuation allowance | 833,810 | 672,172 |  |
Valuation allowance, deferred tax asset, increase (decrease) | 161,600 | 146,600 |  |
Deferred tax liability on indefinite-lived intangibles acquired | $ 55,905 | $ 102,834 |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 21.00% |
Uncertain tax position | $ 0 |  |  |
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174. | 300,300 |  |  |
Undistributed earnings from non-US subsidiaries | 345,900 |  |  |
Undistributed earnings from non-US subsidiaries, tax | 0 |  |  |
Unrecognized tax benefits | 1,360 | $ 27,217 |  |
Agilis |  |  |  |
Operating loss carryforwards |  |  |  |
Deferred tax liability on indefinite-lived intangibles acquired |  |  |  | $ 122,000
Federal |  |  |  |
Operating loss carryforwards |  |  |  |
Net operating loss carryforwards | 287,000 |  |  |
Research and development credit carryforwards | 35,900 |  |  |
Research and development credit carryforwards expiring during the period | 600 |  |  |
Orphan Drug Credit carryover | 169,600 |  |  |
State |  |  |  |
Operating loss carryforwards |  |  |  |
Net operating loss carryforwards | 208,800 |  |  |
Foreign Tax Authority |  |  |  |
Operating loss carryforwards |  |  |  |
Net operating loss carryforwards | $ 12,100 |  |  |

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