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Income taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Schedule of Income before Income Tax, Domestic and Foreign | The loss from operations before tax benefit (expense) consisted of the following for the years ended December 31, 2023, 2022, and 2021: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2023 |  | 2022 |  | 2021
Domestic | ​ | $ | (784,744) | ​ | $ | (591,126) | ​ | $ | (487,726)
Foreign | ​ |  | 88,634 | ​ |  | 3,639 | ​ |  | (30,614)
Total | ​ | $ | (696,110) | ​ | $ | (587,487) | ​ | $ | (518,340)
​
Components of Income Tax Provision | The Income Tax Provision consisted of the following for the years ended December 31, 2023, 2022 and 2021: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2023 |  | 2022 |  | 2021
Current: |  | ​ |  |  | ​ |  |  | ​ |
U.S. Federal | ​ | $ | — | ​ | $ | — | ​ | $ | —
U.S. State and Local | ​ |  | 27,226 | ​ |  | (4,224) | ​ |  | (3,844)
Foreign | ​ |  | (4,003) | ​ |  | (1,582) | ​ |  | (1,340)
Deferred: | ​ |  | ​ | ​ |  | ​ | ​ |  |
U.S. Federal | ​ |  | 36,408 | ​ |  | 23,689 | ​ |  | —
U.S. State and Local | ​ |  | 10,521 | ​ |  | 10,587 | ​ |  | (377)
Foreign | ​ |  | (646) | ​ |  | — | ​ |  | —
Total tax benefit (expense) | ​ | $ | 69,506 | ​ | $ | 28,470 | ​ | $ | (5,561)
Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate | A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31, |
​ |  | 2023 |  | 2022 |  | 2021 |
Federal income tax provision at statutory rate | ​ | 21.00 | % | 21.00 | % | 21.00 | %
State income tax provision, net of federal benefit | ​ | 0.32 |  | 3.07 |  | (0.74) |
Permanent differences | ​ | (1.43) |  | (1.83) |  | (4.06) |
Research and development | ​ | 4.59 |  | 5.89 |  | 4.50 |
Change in valuation allowances | ​ | (16.86) |  | (23.36) |  | (29.03) |
Change in deferred tax assets | ​ | — |  | (0.10) |  | 12.05 |
Foreign tax rate differential | ​ | 0.05 |  | (0.17) |  | 0.01 |
Tax rate change | ​ | (1.26) |  | 0.34 |  | 0.01 |
Release (Accrual) of uncertain tax positions | ​ | 3.71 | ​ | — | ​ | (4.78) | ​
Other | ​ | (0.12) |  | — |  | (0.03) |
Effective income tax rate | ​ | 10.00 | % | 4.84 | % | (1.07) | %
​
Schedule of significant components of the Company's deferred tax assets and liabilities | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | December 31,
​ | ​ | 2023 |  | 2022
Assets: |  | ​ |  |  | ​ |
Noncurrent deferred income taxes | ​ | $ | — | ​ | $ | —
Liabilities: | ​ |  |  | ​ |  |
Noncurrent deferred income taxes | ​ |  | (55,905) | ​ |  | (102,834)
Deferred income taxes - net | ​ | $ | (55,905) | ​ | $ | (102,834)
​ The significant components of the Company’s deferred tax assets and liabilities at December 31, 2023 and 2022 are as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | 2023 |  | 2022
Deferred tax assets: |  | ​ |  |  | ​ |
Accrued expense | ​ | $ | 25,400 | ​ | $ | 2,124
Amortization | ​ |  | 137,808 | ​ |  | 52,532
Federal tax credits | ​ |  | 205,485 | ​ |  | 174,802
State tax credits | ​ |  | 9,817 | ​ |  | 9,787
Federal net operating losses | ​ |  | 60,270 | ​ |  | 69,957
State net operating losses | ​ |  | 18,680 | ​ |  | 10,316
Foreign net operating losses | ​ |  | 4,052 | ​ |  | 4,837
Capitalized research and development costs | ​ |  | 149,683 | ​ |  | 110,219
Share based compensation and other | ​ |  | 30,757 | ​ |  | 27,054
Liability for sale of future royalties | ​ | ​ | 190,659 | ​ | ​ | 185,589
Noncash interest expense | ​ | ​ | 9,410 | ​ | ​ | 30,160
Other comprehensive loss | ​ |  | (728) | ​ |  | (719)
Total gross deferred tax assets | ​ |  | 841,293 | ​ |  | 676,658
Less valuation allowance | ​ |  | (833,810) | ​ |  | (672,172)
Total deferred tax assets, net of valuation allowance | ​ | $ | 7,483 | ​ | $ | 4,486
Deferred tax liabilities: | ​ |  |  | ​ |  |
Depreciation | ​ | $ | (7,483) | ​ | $ | (4,486)
Indefinite lived intangible | ​ |  | (55,905) | ​ |  | (102,834)
Total gross deferred tax liabilities | ​ |  | (63,388) | ​ |  | (107,320)
Net deferred tax assets (liabilities) | ​ | $ | (55,905) | ​ | $ | (102,834)
​
Schedule of unrecognized tax benefits | A reconciliation of the gross amount of unrecognized tax benefits, excluding accrued interest and penalties, is as follows:
​ | ​ | ​
​ | Unrecognized Tax Benefits
Balance at December 31, 2022 | ​ | 27,217
Reductions based on settlements or expiration of statute of limitations |  | (24,671)
Interest received | ​ | (1,186)
Balance at December 31, 2023 | $ | 1,360

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