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v3.24.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Cash flows from operating activities |  |  |
Net Income (Loss) | $ (626,604) | $ (559,017) | $ (523,901)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 236,590 | 128,836 | 64,134
Non-cash operating lease expense | 9,827 | 9,884 | 7,386
Non-cash royalty revenue related to sale of future royalties | (93,460) | (48,738) | (23,460)
Non-cash interest expense on liability related to sale of future royalties | 104,790 | 72,639 | 77,683
Intangible asset impairment | 217,800 | 33,384 |
Change in valuation of contingent consideration | (127,700) | (25,900) | (500)
Unrealized loss on ClearPoint Equity Investments | 1,515 | 3,560 | 6,078
Unrealized loss on ClearPoint convertible debt security | 2,678 | 5,740 | 8,281
Unrealized (gain) loss on marketable securities - equity investments | (2,517) | 7,992 | (1,673)
Realized loss for the sale of Clearpoint Equity Investment | 782 |  |
Realized gain on redemption of marketable securities- equity investments | (4,383) |  |
Non-cash stock consideration, milestone payment | 29,570 |  |
Disposal of asset | 806 | 80 |
Amortization of (discounts) premiums on investments, net | (2,200) | 1,713 | 5,299
Deferred income taxes | (46,930) | (34,276) | 377
Amortization of debt issuance costs | 1,873 | 1,901 | 1,848
Loss on extinguishment of debt | 55,625 |  |
Share-based compensation expense | 101,636 | 110,333 | 103,513
Unrealized foreign currency transaction (gains) losses, net | (14,113) | 13,263 | 47,391
Non cash foreign currency remeasurement loss on intercompany loan |  | 16,887 |
Changes in operating assets and liabilities: |  |  |
Inventory, net | (8,183) | (6,668) | 1,800
Prepaid expenses and other current assets | (44,992) | (51,621) | (15,310)
Trade and royalty receivables, net | (1,539) | (48,468) | (44,991)
Deposits and other assets | 5,222 | (2,913) | (232)
Accounts payable and accrued expenses | 48,346 | 27,542 | 45,659
Other liabilities | (2,307) | (4,558) | (6,704)
Deferred revenue | (550) | 1,351 | (4,010)
Payments on contingent consideration |  | (9,600) |
Net cash used in operating activities | (158,418) | (356,654) | (251,332)
Cash flows from investing activities |  |  |
Purchases of fixed assets | (28,438) | (32,016) | (28,213)
Purchases of marketable securities - available for sale | (174,086) | (52,764) | (333,148)
Purchases of marketable securities - equity investments | (38,398) | (22,787) | (210,018)
Sale and redemption of marketable securities- available for sale | 21,544 | 405,234 | 843,498
Sale and redemption of marketable securities - equity investments | 132,228 | 112,958 | 4,281
Sale and redemption of ClearPoint Equity Investments | 2,594 |  |
Acquisition of product rights and licenses | (92,181) | (120,444) | (57,118)
Purchase of equity investment in ClearPoint |  |  | (100)
Net cash (used in) provided by investing activities | (176,737) | 290,181 | 219,182
Cash flows from financing activities |  |  |
Proceeds from exercise of options | 24,040 | 14,632 | 17,309
Repayment of senior secured term loan | (300,000) |  |
Debt extinguishment costs related to senior secured term loan | (81,933) |  |
Cash consideration received from Royalty Purchase Agreement | 1,000,000 |  |
Debt issuance costs related to secured term loan | (282) | (11,454) |
Proceeds from issuance of senior secured term loan |  | 300,000 |
Repayment of Convertible Notes |  | (150,000) |
Payments on deferred and contingent consideration obligation |  | (40,400) |
Proceeds from employee stock purchase plan | 5,954 | 6,450 | 5,792
Payment of finance lease principal | (1,379) | (1,276) | (2,224)
Proceeds from stock purchase agreement |  | 50,000 |
Net cash provided by financing activities | 646,400 | 167,952 | 20,877
Effect of exchange rate changes on cash | 3,114 | (2,772) | (7,821)
Net increase (decrease) in cash and cash equivalents | 314,359 | 98,707 | (19,094)
Cash and cash equivalents, and restricted cash beginning of period | 295,925 | 197,218 | 216,312
Cash and cash equivalents, and restricted cash end of period | 610,284 | 295,925 | 197,218
Supplemental disclosure of cash information |  |  |
Cash paid for interest | 36,131 | 18,463 | 9,588
Cash paid for income taxes | 14,155 | 4,922 | 7,708
Supplemental disclosure of non-cash investing and financing activity |  |  |
Unrealized gain (loss) on marketable securities, net of tax | 820 | 108 | (2,502)
Right-of-use assets obtained in exchange for operating lease obligations |  | 35,817 | 645
Acquisition of product rights and licenses | 54,618 | 33,239 | $ 22,294
Milestone payable | $ 2,500 |  |
Debt issuance costs related to senior secured term loan |  | 159 |
Capital expenditures unpaid at the end of period |  | $ 308 |

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- Definition Amount, after tax and reclassification adjustment, of gain (loss) in value of unsold investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale), attributable to parent. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 810 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 19 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481231/810-10-45-19 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 20 -SubTopic 10 -Topic 810 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481231/810-10-45-20 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 1A -Subparagraph (c)(3) -SubTopic 10 -Topic 810 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481203/810-10-50-1A + Details
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- Definition Amount of cash outflow for cost from early extinguishment and prepayment of debt. Includes, but is not limited to, third-party cost, premium paid, and other fee paid to lender directly for debt extinguishment or debt prepayment. Excludes accrued interest. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 15 -Subparagraph (g) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-15 + Details
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- Definition The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (e) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-15 + Details
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- Definition Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481830/320-10-45-11 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-13 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-11 + Details
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- Definition The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-13 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-13 + Details
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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481830/320-10-45-11 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-13 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 + Details
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- Definition Amount of cash inflow from sale of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org//1943274/2147481830/320-10-45-11 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 9 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org//1943274/2147481800/320-10-50-9 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-12 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-11 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2A -Subparagraph (a) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2A + Details
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- Definition The cash outflow to repay long-term debt that is wholly or partially secured by collateral. Excludes repayments of tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-15 + Details
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- Definition Amount of increase in right-of-use asset obtained in exchange for operating lease liability. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 842 -SubTopic 20 -Name Accounting Standards Codification -Section 55 -Paragraph 53 -Publisher FASB -URI https://asc.fasb.org//1943274/2147479589/842-20-55-53 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 842 -SubTopic 20 -Name Accounting Standards Codification -Section 50 -Paragraph 4 -Subparagraph (g)(2) -Publisher FASB -URI https://asc.fasb.org//1943274/2147478964/842-20-50-4 + Details
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