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Consolidated Statements of Stockholders' (Deficit) Equity - USD ($) $ in Thousands | Common stock | Additional paid-in capital Cumulative Effect Adjustment | Additional paid-in capital | Accumulated other comprehensive (loss) income | Accumulated deficit Cumulative Effect Adjustment | Accumulated deficit | Cumulative Effect Adjustment | Total
--- | --- | --- | --- | --- | --- | --- | --- | ---
Balance (in shares) at Dec. 31, 2020 | 69,718,096 |  |  |  |  |  |  |
Balance at the beginning of the period at Dec. 31, 2020 | $ 70 | $ (175,236) | $ 2,171,746 | $ (60,957) | $ 54,796 | $ (1,628,877) | $ (120,440) | $ 481,982
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |
Exercise of options (in shares) | 635,871 |  |  |  |  |  |  |
Exercise of options | $ 1 |  | 17,308 |  |  |  |  | 17,309
Restricted stock vesting and issuance (in shares) | 307,658 |  |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 166,601 |  |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  |  | 5,792 |  |  |  |  | 5,792
Share-based compensation expense |  |  | 103,513 |  |  |  |  | 103,513
Receivable from investor |  |  | 483 |  |  |  |  | 483
Other |  |  |  |  |  | 25 |  | 25
Net Income (Loss) |  |  |  |  |  | (523,901) |  | (523,901)
Comprehensive income |  |  |  | 36,675 |  |  |  | 36,675
Balance (in shares) at Dec. 31, 2021 | 70,828,226 |  |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2021 | $ 71 |  | 2,123,606 | (24,282) |  | (2,097,957) |  | 1,438
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |
Issuance of common stock related to stock purchase agreement (in shares) | 1,095,290 |  |  |  |  |  |  |
Issuance of common stock related to stock purchase agreement | $ 1 |  | 49,999 |  |  |  |  | 50,000
Exercise of options (in shares) | 496,863 |  |  |  |  |  |  |
Exercise of options |  |  | 14,632 |  |  |  |  | 14,632
Restricted stock vesting and issuance (in shares) | 490,008 |  |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 194,305 |  |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  |  | 6,450 |  |  |  |  | 6,450
Share-based compensation expense |  |  | 110,333 |  |  |  |  | 110,333
Net Income (Loss) |  |  |  |  |  | (559,017) |  | (559,017)
Comprehensive income |  |  |  | 29,078 |  |  |  | 29,078
Balance (in shares) at Dec. 31, 2022 | 73,104,692 |  |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2022 | $ 72 |  | 2,305,020 | 4,796 |  | (2,656,974) |  | (347,086)
Increase (Decrease) in Stockholders' Equity |  |  |  |  |  |  |  |
Exercise of options (in shares) | 822,482 |  |  |  |  |  |  |
Exercise of options | $ 1 |  | 24,039 |  |  |  |  | 24,040
Restricted stock vesting and issuance (in shares) | 915,203 |  |  |  |  |  |  |
Restricted stock vesting and issuance, net | $ 1 |  |  |  |  |  |  | 1
Issuance of common stock in connection with an employee stock purchase plan (in shares) | 209,050 |  |  |  |  |  |  |
Issuance of common stock in connection with an employee stock purchase plan |  |  | 5,954 |  |  |  |  | 5,954
Issuance of common stock in connection with a milestone payable (in shares) | 657,462 |  |  |  |  |  |  |
Issuance of common stock in connection with a milestone payable | $ 1 |  | 29,569 |  |  |  |  | 29,570
Share-based compensation expense |  |  | 101,636 |  |  |  |  | 101,636
Receivable from investor |  |  | 15 |  |  |  |  | 15
Net Income (Loss) |  |  |  |  |  | (626,604) |  | (626,604)
Comprehensive income |  |  |  | (6,081) |  |  |  | (6,081)
Balance (in shares) at Dec. 31, 2023 | 75,708,889 |  |  |  |  |  |  |
Balance at the end of the period at Dec. 31, 2023 | $ 75 |  | $ 2,466,233 | $ (1,285) |  | $ (3,283,578) |  | $ (818,555)

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