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Summary of significant accounting policies - Narrative (Details) $ in Thousands | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jun. 30, 2022 USD ($) | Jun. 30, 2023 USD ($) | Dec. 31, 2023 USD ($) segment | Dec. 31, 2023 USD ($) country | Dec. 31, 2023 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2023 USD ($) item | Dec. 31, 2022 USD ($) country segment | Dec. 31, 2021 USD ($) country | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  | 1 |  |  |  |  | 1 |  |  |
Number of reporting units |  |  | 1 |  |  |  | 1 |  |  |  |
Allowance for credit loss |  |  | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 |  |  |
Increase in allowance for credit losses |  |  |  |  | 0 |  |  | 0 |  |  |
Allowance for doubtful accounts receivable |  |  | 1,200 | 1,200 | 1,200 | $ 1,200 | 1,200 | 300 |  |  |
Bad debt expense |  |  |  |  | 900 |  |  | 200 | $ 100 |  |
Revenue |  |  |  |  | 937,822 |  |  | 698,801 | 538,593 |  |
Cash consideration received from Royalty Purchase Agreement |  |  |  |  | 1,000,000 |  |  |  |  |  |
State income tax provision |  |  |  |  | (27,226) |  |  | $ 4,224 | $ 3,844 |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Federal income tax statutory rate |  |  |  |  |  | 21.00% |  | 21.00% | 21.00% |  |
Deferred tax liability |  |  | 63,388 | 63,388 | 63,388 | $ 63,388 | 63,388 | $ 107,320 |  |  |
Deferred tax benefit |  |  |  |  | 46,930 |  |  | 34,276 | $ (377) |  |
Impairment of long-lived assets |  |  |  |  | 0 |  |  |  |  |  |
Non cash realized foreign exchange loss |  |  |  |  |  |  |  | 16,887 |  |  |
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174. |  |  |  |  | 300,300 |  |  |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  | 217,800 |  |  | 33,384 |  |  |
Impairment of goodwill |  |  |  |  | 0 |  |  |  |  |  |
Upstaza |  |  |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  | 0 |  |  |  |  |  |
Indefinite-lived intangible assets |  |  |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  | 217,800 |  |  |  |  |  |
Indefinite-lived intangible assets | PTC-FA and PTC-AS |  |  |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  | $ 217,800 |  |  | 217,800 |  |  |  |  |  |
Indefinite-lived intangible assets | Upstaza |  |  |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Impairment of indefinite-lived intangibles excluding goodwill |  |  |  |  | 0 |  |  |  |  |  |
Agilis |  |  |  |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |  |  |  |
Deferred tax liability |  |  |  |  |  |  |  |  |  |  | $ 122,000
Impairment of goodwill |  |  |  |  | 0 |  |  |  |  |  |
Prepaids and other current assets |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Deferred research and development advance payments, short-term |  |  | 2,600 | 2,600 | 2,600 | 2,600 | 2,600 | 2,400 |  |  |
Deposits and other assets |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Bank guarantee denominated in foreign currency |  |  | 600 | 600 | 600 | 600 | 600 |  |  |  |
Deferred research and development advance payments, long-term |  |  | $ 4,700 | $ 4,700 | 4,700 | $ 4,700 | $ 4,700 | 3,900 |  |  |
Hopewell Campus | Minimum |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Term for letter of credit (in years) |  |  |  |  |  |  |  |  |  | 5 years |
Hopewell Campus | Deposits and other assets |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Letters of credit |  |  |  |  |  |  |  |  |  | $ 7,500 |
Hopewell Campus | Fifth Anniversary |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Letters of credit |  |  |  |  |  |  |  |  |  | $ 3,800 |
Term for letter of credit (in years) |  |  |  |  |  |  |  |  |  | 5 years |
Warren Premises |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Period after which letter of credit may be reduced if lease is not in default | 5 years |  |  |  |  |  |  |  |  |  |
Warren Premises | Deposits and other assets |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Letters of credit | $ 8,100 |  |  |  |  |  |  |  |  |  |
Warren Premises | Fifth Anniversary |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Letters of credit | $ 4,100 |  |  |  |  |  |  |  |  |  |
Non-US |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 406,161 |  |  | 316,939 |  |  |
United States |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 531,661 |  |  | $ 381,862 |  |  |
Net product revenue | Geographic concentration risk |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of countries exceeding 10% of net product sales | country |  |  |  | 2 |  |  |  | 2 | 1 |  |
Percentage of net product sales threshold |  |  |  |  |  | 10.00% |  | 10.00% | 10.00% |  |
Net product revenue |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 661,249 |  |  | $ 535,228 | $ 428,904 |  |
Net product revenue | Non-US |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 406,100 |  |  | 316,900 | 241,600 |  |
Net product revenue | Net product revenue | Geographic concentration risk | Russia |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 86,000 |  |  | 59,700 |  |  |
Net product revenue | Net product revenue | Geographic concentration risk | United States |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 255,100 |  |  | 218,300 |  |  |
Emflaza | United States |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 255,100 |  |  | 218,300 | 187,300 |  |
Translarna | Non-US |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 355,800 |  |  | $ 288,600 | $ 236,000 |  |

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