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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($)
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Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.90 |  |
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.059 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Potential milestones | $ 0 | $ 0 |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Potential milestones | $ 31,000,000 | $ 331,000,000 |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.85 | 0.25 |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.92 | 0.92 |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.058 | 0.062 |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.061 | 0.083 |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) |  |  |
Fair Value Valuation Inputs |  |  |
Fair value | $ 26,600,000 |  |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments |  |  |
Fair Value Valuation Inputs |  |  |
Fair value | $ 26,600,000 | $ 82,500,000 | $ 139,300,000
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.93 |  |
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.110 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Potential milestones | $ 0 | 0 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Potential milestones | $ 50,000,000 | $ 150,000,000 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.85 | 0.25 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 1 | 1 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement |  | 0.02 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement |  | 0.06 |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate |  |  |
Fair Value Valuation Inputs |  |  |
Rights Exchange Settlement measurement | 0.11 | 0.115 |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) |  |  |
Fair Value Valuation Inputs |  |  |
Fair value | $ 9,700,000 |  |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments |  |  |
Fair Value Valuation Inputs |  |  |
Fair value | $ 9,700,000 | $ 81,500,000 | $ 100,600,000

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