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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2022 | Dec. 31, 2021 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Collaboration and royalty revenue |  |  |  |  |
Revenue |  |  | $ 937,822 | $ 698,801 | $ 538,593
Collaboration revenue |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Revenue |  |  | 100,030 | 50,052 | 55,046
Royalty revenue |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Revenue |  |  | 168,856 | 113,521 | 54,643
SMA License Agreement | Collaboration revenue |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Revenue |  |  | 100,000 | 50,100 | 55,000
SMA License Agreement | Royalty revenue |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Revenue |  |  | 168,900 | $ 113,500 | $ 54,600
SMA License Agreement | Sales Milestones |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Net sales milestone threshold achieved | $ 750,000 | $ 500,000 | 1,500,000 |  |
SMA License Agreement | Sales Milestones | Prepaids and other current assets |  |  |  |  |
Collaboration and royalty revenue |  |  |  |  |
Milestone payments due | $ 50,000 | $ 25,000 | $ 100,000 |  |

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