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Income taxes - Tax Rate Reconciliation (Details) | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate |  |  |
Federal income tax provision at statutory rate | 21.00% | 21.00% | 21.00%
State income tax provision, net of federal benefit | 0.32% | 3.07% | (0.74%)
Permanent differences | (1.43%) | (1.83%) | (4.06%)
Research and development | 4.59% | 5.89% | 4.50%
Change in valuation allowances | (16.86%) | (23.36%) | (29.03%)
Change in deferred tax assets |  | (0.10%) | 12.05%
Foreign tax rate differential | 0.05% | (0.17%) | 0.01%
Tax rate change | (1.26%) | 0.34% | 0.01%
Release (accrual) of uncertain tax positions | 3.71% |  | (4.78%)
Other | (0.12%) |  | (0.03%)
Effective income tax rate | 10.00% | 4.84% | (1.07%)

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