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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Sep. 30, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) payment | Aug. 31, 2021 USD ($) | Mar. 31, 2021 USD ($) | Nov. 30, 2011 USD ($)
Revenue recognition |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  | $ 150,000 |  |  |  |  |
Revenue |  |  | 937,822 | $ 698,801 | $ 538,593 |  |  |
Collaboration revenue |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Revenue |  |  | 100,030 | 50,052 | 55,046 |  |  |
Royalty revenue |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Revenue |  |  | 168,856 | 113,521 | 54,643 |  |  |
SMA License Agreement | Collaboration revenue |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Revenue |  |  | 100,000 | 50,100 | 55,000 |  |  |
SMA License Agreement | Royalty revenue |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Revenue |  |  | 168,900 | $ 113,500 | $ 54,600 |  |  |
Research and Development and Sales Milestones | Collaboration revenue |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Number of milestone payments. | payment |  |  |  |  | 3 |  |  |
Research And Development Event Milestones | SMA License Agreement |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  | 0 |  |  |  |  |
Milestone payments received |  |  |  |  |  | $ 10,000 | $ 20,000 |
Sales Milestones | SMA License Agreement |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  | 150,000 |  |  |  |  |
Net sales milestone threshold achieved | $ 750,000 | $ 500,000 | 1,500,000 |  |  |  |  |
Sales Milestones | SMA License Agreement | Prepaids and other current assets |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Milestone payments due | $ 50,000 | $ 25,000 | $ 100,000 |  |  |  |  |
Maximum | Research And Development Event Milestones | SMA License Agreement | Roche |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  |  | $ 135,000
Maximum | Sales Milestones | SMA License Agreement | Roche |  |  |  |  |  |  |  |
Revenue recognition |  |  |  |  |  |  |  |
Remaining potential milestones that can be achieved |  |  |  |  |  |  |  | $ 325,000

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