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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jul. 31, 2022 | Dec. 31, 2023 | Dec. 31, 2022
Changes in the fair value of warrant liability and SARs liability |  |  |
Change in fair value - Income Statement location |  | Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset |
PTC-FA and PTC-AS |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Change in fair value |  | $ 128,400 |
Ending Balance |  | 0 |
Upstaza |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Ending Balance |  | 36,300 |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Agilis |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Ending Balance |  | 26,600 |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Agilis | Commitments |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Beginning Balance |  | 82,500 | $ 139,300
Change in fair value |  | (55,900) | (6,800)
Payments | $ (50,000) |  | (50,000)
Ending Balance |  | 26,600 | 82,500
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Agilis |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Ending Balance |  | 9,700 |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Agilis | Commitments |  |  |
Changes in the fair value of warrant liability and SARs liability |  |  |
Beginning Balance |  | 81,500 | 100,600
Change in fair value |  | (71,800) | (19,100)
Ending Balance |  | $ 9,700 | $ 81,500

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- Definition Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 820 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 + Details
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- Definition Amount of purchases, (sales), issuances and (settlements) of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482106/820-10-50-2 + Details
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