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Intangible assets and goodwill - (Tables)
12 Months Ended
Dec. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract]  
Schedule of definite lived intangible assets

Definite lived intangible assets consisted of the following at December 31, 2023 and 2022:

Ending Balance at

Foreign

Ending Balance at

Definite-lived

December 31,

currency

December 31,

intangibles assets, gross

    

2022

    

Additions

    

translation

    

2023

Emflaza

$

420,253

$

107,164

$

$

527,417

Waylivra

9,316

533

369

10,218

Tegsedi

7,109

5,839

374

13,322

Upstaza

89,550

89,550

Total definite-lived intangibles, gross

$

526,228

$

113,536

$

743

$

640,507

Ending Balance at

Foreign

Ending Balance at

Definite-lived

December 31,

currency

December 31,

intangibles assets, accumulated amortization

    

2022

    

Amortization

    

translation

    

2023

Emflaza

$

(266,023)

$

(212,595)

$

$

(478,618)

Waylivra

(2,751)

(1,080)

(134)

(3,965)

Tegsedi

(1,709)

(1,498)

(104)

(3,311)

Upstaza

(3,420)

(7,462)

(10,882)

Total definite-lived intangibles, accumulated amortization

$

(273,903)

$

(222,635)

$

(238)

$

(496,776)

Total definite-lived intangibles, net

$

143,731

Schedule of estimated future amortization of intangible assets

The estimated future amortization of the Emflaza rights, Waylivra, Tegsedi, and Upstaza intangible assets is expected to be as follows:

    

As of December 31, 2023

2024

$

59,312

2025

 

10,512

2026

 

10,512

2027

 

10,512

2028 and thereafter

 

52,883

Total

$

143,731

Schedule of indefinite lived intangible assets

Indefinite lived intangible assets consisted of the following at December 31, 2023 and 2022:

Ending Balance at

Reclass from

Foreign

Ending Balance at

Indefinite-lived

December 31,

Indefinite Lived to

currency

December 31,

intangibles assets

    

2022

    

Additions

    

Definite Lived

    

Impairment

    

translation

    

2023

Upstaza

$

235,766

$

$

$

$

$

235,766

PTC-FA

112,500

(112,500)

PTC-AS

105,300

(105,300)

Total indefinite-lived intangibles

$

453,566

$

$

$

(217,800)

$

$

235,766

Total intangible assets, net

$

379,497