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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Jun. 30, 2022
USD ($)
Jun. 30, 2023
USD ($)
Dec. 31, 2023
USD ($)
segment
Dec. 31, 2023
USD ($)
country
Dec. 31, 2023
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2023
USD ($)
item
Dec. 31, 2022
USD ($)
country
segment
Dec. 31, 2021
USD ($)
country
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Number of operating segments | segment     1         1      
Number of reporting units     1       1        
Allowance for credit loss     $ 0 $ 0 $ 0 $ 0 $ 0 $ 0      
Increase in allowance for credit losses         0     0      
Allowance for doubtful accounts receivable     1,200 1,200 1,200 $ 1,200 1,200 300      
Bad debt expense         900     200 $ 100    
Revenue         937,822     698,801 538,593    
Cash consideration received from Royalty Purchase Agreement         1,000,000            
State income tax provision         (27,226)     $ 4,224 $ 3,844    
Income taxes                      
Federal income tax statutory rate           21.00%   21.00% 21.00%    
Deferred tax liability     63,388 63,388 63,388 $ 63,388 63,388 $ 107,320      
Deferred tax benefit         46,930     34,276 $ (377)    
Impairment of long-lived assets         0            
Non cash realized foreign exchange loss               16,887      
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174.         300,300            
Impairment of indefinite-lived intangibles excluding goodwill         217,800     33,384      
Impairment of goodwill         0            
Upstaza                      
Income taxes                      
Impairment of indefinite-lived intangibles excluding goodwill         0            
Indefinite-lived intangible assets                      
Income taxes                      
Impairment of indefinite-lived intangibles excluding goodwill         217,800            
Indefinite-lived intangible assets | PTC-FA and PTC-AS                      
Income taxes                      
Impairment of indefinite-lived intangibles excluding goodwill   $ 217,800     217,800            
Indefinite-lived intangible assets | Upstaza                      
Income taxes                      
Impairment of indefinite-lived intangibles excluding goodwill         0            
Agilis                      
Income taxes                      
Deferred tax liability                     $ 122,000
Impairment of goodwill         0            
Prepaids and other current assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Deferred research and development advance payments, short-term     2,600 2,600 2,600 2,600 2,600 2,400      
Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Bank guarantee denominated in foreign currency     600 600 600 600 600        
Deferred research and development advance payments, long-term     $ 4,700 $ 4,700 4,700 $ 4,700 $ 4,700 3,900      
Hopewell Campus | Minimum                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Term for letter of credit (in years)                   5 years  
Hopewell Campus | Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit                   $ 7,500  
Hopewell Campus | Fifth Anniversary                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit                   $ 3,800  
Term for letter of credit (in years)                   5 years  
Warren Premises                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Period after which letter of credit may be reduced if lease is not in default 5 years                    
Warren Premises | Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit $ 8,100                    
Warren Premises | Fifth Anniversary                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit $ 4,100                    
Non-US                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         406,161     316,939      
United States                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         531,661     $ 381,862      
Net product revenue | Geographic concentration risk                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Number of countries exceeding 10% of net product sales | country       2       2 1    
Percentage of net product sales threshold           10.00%   10.00% 10.00%    
Net product revenue                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         661,249     $ 535,228 $ 428,904    
Net product revenue | Non-US                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         406,100     316,900 241,600    
Net product revenue | Net product revenue | Geographic concentration risk | Russia                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         86,000     59,700      
Net product revenue | Net product revenue | Geographic concentration risk | United States                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         255,100     218,300      
Emflaza | United States                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         255,100     218,300 187,300    
Translarna | Non-US                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue         $ 355,800     $ 288,600 $ 236,000