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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Sep. 30, 2022
Dec. 31, 2021
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Collaboration and royalty revenue          
Revenue     $ 937,822 $ 698,801 $ 538,593
Collaboration revenue          
Collaboration and royalty revenue          
Revenue     100,030 50,052 55,046
Royalty revenue          
Collaboration and royalty revenue          
Revenue     168,856 113,521 54,643
SMA License Agreement | Collaboration revenue          
Collaboration and royalty revenue          
Revenue     100,000 50,100 55,000
SMA License Agreement | Royalty revenue          
Collaboration and royalty revenue          
Revenue     168,900 $ 113,500 $ 54,600
SMA License Agreement | Sales Milestones          
Collaboration and royalty revenue          
Net sales milestone threshold achieved $ 750,000 $ 500,000 1,500,000    
SMA License Agreement | Sales Milestones | Prepaids and other current assets          
Collaboration and royalty revenue          
Milestone payments due $ 50,000 $ 25,000 $ 100,000