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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Jul. 31, 2022
Dec. 31, 2023
Dec. 31, 2022
Changes in the fair value of warrant liability and SARs liability      
Change in fair value - Income Statement location   Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Asset  
PTC-FA and PTC-AS      
Changes in the fair value of warrant liability and SARs liability      
Change in fair value   $ 128,400  
Ending Balance   0  
Upstaza      
Changes in the fair value of warrant liability and SARs liability      
Ending Balance   36,300  
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Agilis      
Changes in the fair value of warrant liability and SARs liability      
Ending Balance   26,600  
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Agilis | Commitments      
Changes in the fair value of warrant liability and SARs liability      
Beginning Balance   82,500 $ 139,300
Change in fair value   (55,900) (6,800)
Payments $ (50,000)   (50,000)
Ending Balance   26,600 82,500
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Agilis      
Changes in the fair value of warrant liability and SARs liability      
Ending Balance   9,700  
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Agilis | Commitments      
Changes in the fair value of warrant liability and SARs liability      
Beginning Balance   81,500 100,600
Change in fair value   (71,800) (19,100)
Ending Balance   $ 9,700 $ 81,500