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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	1 Months Ended		12 Months Ended
	Sep. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($) payment	Aug. 31, 2021 USD ($)	Mar. 31, 2021 USD ($)	Nov. 30, 2011 USD ($)
Revenue recognition
Remaining potential milestones that can be achieved			$ 150,000
Revenue			937,822	$ 698,801	$ 538,593
Collaboration revenue
Revenue recognition
Revenue			100,030	50,052	55,046
Royalty revenue
Revenue recognition
Revenue			168,856	113,521	54,643
SMA License Agreement | Collaboration revenue
Revenue recognition
Revenue			100,000	50,100	55,000
SMA License Agreement | Royalty revenue
Revenue recognition
Revenue			168,900	$ 113,500	$ 54,600
Research and Development and Sales Milestones | Collaboration revenue
Revenue recognition
Number of milestone payments. | payment					3
Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved			0
Milestone payments received						$ 10,000	$ 20,000
Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved			150,000
Net sales milestone threshold achieved	$ 750,000	$ 500,000	1,500,000
Sales Milestones | SMA License Agreement | Prepaids and other current assets
Revenue recognition
Milestone payments due	$ 50,000	$ 25,000	$ 100,000
Maximum | Research And Development Event Milestones | SMA License Agreement | Roche
Revenue recognition
Remaining potential milestones that can be achieved								$ 135,000
Maximum | Sales Milestones | SMA License Agreement | Roche
Revenue recognition
Remaining potential milestones that can be achieved								$ 325,000

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