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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis $ in Thousands | Mar. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Mar. 31, 2023 USD ($) | Dec. 31, 2022 USD ($)
--- | --- | --- | --- | ---
Significant unobservable inputs (Level 3) | Upstaza |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 36,200 |  |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | 0 | $ 0 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 31,000 | $ 31,000 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.85 | 0.85 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.92 | 0.92 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.059 | 0.058 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.062 | 0.061 |  |
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.90 |  |  |
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.060 |  |  |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 26,900 | $ 26,600 | $ 85,500 | $ 82,500
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | 0 | 0 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Potential milestones | $ 50,000 | $ 50,000 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.85 | 0.85 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 1 | 1 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0 | 0 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.135 | 0.11 |  |
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.93 |  |  |
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Rights Exchange Settlement measurement | 0.135 |  |  |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments |  |  |  |
Fair Value Valuation Inputs |  |  |  |
Fair value | $ 9,300 | $ 9,700 | $ 80,900 | $ 81,500

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