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Summary of significant accounting policies - Narrative (Details) $ in Thousands |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 22, 2017 | Jun. 30, 2022 USD ($) | Mar. 31, 2024 USD ($) country segment | Mar. 31, 2023 USD ($) segment country | Dec. 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Number of operating segments | segment |  |  | 1 | 1 |  |  |  |
Allowance for credit loss |  |  | $ 0 | $ 0 |  |  |  |
Increase in allowance for credit losses |  |  | 0 | 0 |  |  |  |
Allowance for doubtful accounts receivable |  |  | 1,100 |  |  | $ 1,200 |  |
Revenue |  |  | 210,118 | 220,382 |  |  |  |
Income taxes |  |  |  |  |  |  |  |
Federal income tax statutory rate | 21.00% |  |  |  |  |  |  |
Deferred tax benefit |  |  | 1 | $ 4 |  | $ 46,900 |  |
Forecast |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174. |  |  |  |  | $ 42,600 |  |  |
Agilis |  |  |  |  |  |  |  |
Income taxes |  |  |  |  |  |  |  |
Deferred tax liability |  |  |  |  |  |  |  | $ 122,000
Deposits and other assets |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Bank guarantee denominated in foreign currency |  |  | $ 600 |  |  |  |  |
Hopewell Campus |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Period after which letter of credit may be reduced if lease is not in default |  |  |  |  |  |  | 5 years |
Hopewell Campus | Minimum |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Term for letter of credit (in years) |  |  |  |  |  |  | 5 years |
Hopewell Campus | Deposits and other assets |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Letters of credit |  |  |  |  |  |  | $ 7,500 |
Hopewell Campus | Fifth Anniversary |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Letters of credit |  |  |  |  |  |  | $ 3,800 |
Warren Premises |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Period after which letter of credit may be reduced if lease is not in default |  | 5 years |  |  |  |  |  |
Warren Premises | Deposits and other assets |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Letters of credit |  | $ 8,100 |  |  |  |  |  |
Warren Premises | Fifth Anniversary |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Letters of credit |  | $ 4,100 |  |  |  |  |  |
Net product revenue | Geographic concentration risk |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Number of countries exceeding 10% of net product sales | country |  |  | 2 | 3 |  |  |  |
Percentage of net product sales threshold |  |  | 10.00% | 10.00% |  |  |  |
Net product revenue | Geographic concentration risk | Non-US |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | $ 120,100 | $ 133,000 |  |  |  |
Net product revenue | Geographic concentration risk | Russia |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | 52,600 | 44,600 |  |  |  |
Net product revenue | Geographic concentration risk | Brazil |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  |  | 25,900 |  |  |  |
Net product revenue | Geographic concentration risk | United States |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | $ 57,500 | $ 54,600 |  |  |  |
Net product revenue | Customer concentration risk |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Percentage of net product sales threshold |  |  | 10.00% | 10.00% |  |  |  |
Net product revenue |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | $ 177,604 | $ 187,557 |  |  |  |
Emflaza | Net product revenue | Geographic concentration risk | United States |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | 57,500 | 54,600 |  |  |  |
Translarna | Net product revenue | Geographic concentration risk | Non-US |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |
Revenue |  |  | $ 103,600 | $ 115,100 |  |  |  |

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