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Stock award plan - (Tables)

3 Months Ended

Mar. 31, 2024

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2023		9,600,399	​	$	43.59				​	​
Granted		855,385	​	$	25.69				​	​
Exercised		(109,892)	​	$	19.22				​	​
Forfeited/Cancelled		(815,707)	​	$	45.32				​	​
Outstanding at March 31, 2024		9,530,185	​	$	42.12		5.90	years	​	$	12,025
Vested or Expected to vest at March 31, 2024		2,112,348	​	$	38.57		8.67	years	​	$	2,949
Exercisable at March 31, 2024		7,173,552	​	$	43.44		4.98	years	​	$	8,598

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Schedule of assumptions used to estimate fair values of grants made on the date of grant

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​	​	​	​
​		Three months ended
​		March 31, 2024
Risk-free interest rate		4.23%
Expected volatility		53%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Awards and Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2023	​	2,866,270	​	$	41.82
Granted		1,785,660	​	​	25.69
Vested		(835,179)	​	​	44.56
Forfeited		(86,585)	​	​	40.98
Unvested at March 31, 2024		3,730,166	​	$	33.51

Schedule of share-based compensation expense recorded in the statement of operations

​

​	​	​	​	​	​	​	​
​	​	Three Months Ended March 31,					​
​		2024			2023
Research and development	​	$	8,967	​	$	15,314	​
Selling, general and administrative	​		9,411	​		13,501	​
Total	​	$	18,378	​	$	28,815	​

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
-Subparagraph (c)
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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