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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Dec. 22, 2017
Jun. 30, 2022
USD ($)
Mar. 31, 2024
USD ($)
country
segment
Mar. 31, 2023
USD ($)
segment
country
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Number of operating segments | segment     1 1        
Allowance for credit loss     $ 0 $ 0        
Increase in allowance for credit losses     0 0        
Allowance for doubtful accounts receivable     1,100     $ 1,200    
Revenue     210,118 220,382        
Income taxes                
Federal income tax statutory rate 21.00%              
Deferred tax benefit     1 $ 4   $ 46,900    
Forecast                
Income taxes                
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174.         $ 42,600      
Agilis                
Income taxes                
Deferred tax liability               $ 122,000
Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Bank guarantee denominated in foreign currency     $ 600          
Hopewell Campus                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Period after which letter of credit may be reduced if lease is not in default             5 years  
Hopewell Campus | Minimum                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Term for letter of credit (in years)             5 years  
Hopewell Campus | Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit             $ 7,500  
Hopewell Campus | Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit             $ 3,800  
Warren Premises                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Period after which letter of credit may be reduced if lease is not in default   5 years            
Warren Premises | Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit   $ 8,100            
Warren Premises | Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit   $ 4,100            
Net product revenue | Geographic concentration risk                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Number of countries exceeding 10% of net product sales | country     2 3        
Percentage of net product sales threshold     10.00% 10.00%        
Net product revenue | Geographic concentration risk | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     $ 120,100 $ 133,000        
Net product revenue | Geographic concentration risk | Russia                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     52,600 44,600        
Net product revenue | Geographic concentration risk | Brazil                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       25,900        
Net product revenue | Geographic concentration risk | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     $ 57,500 $ 54,600        
Net product revenue | Customer concentration risk                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Percentage of net product sales threshold     10.00% 10.00%        
Net product revenue                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     $ 177,604 $ 187,557        
Emflaza | Net product revenue | Geographic concentration risk | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     57,500 54,600        
Translarna | Net product revenue | Geographic concentration risk | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue     $ 103,600 $ 115,100