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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Cash flows from operating activities    
Net Income (Loss) $ (91,576) $ (138,959)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 55,395 42,825
Non-cash operating lease expense 1,792 2,942
Non-cash royalty revenue related to sale of future royalties (25,228) (13,237)
Non-cash interest expense on liability related to sale of future royalties 50,064 18,902
Change in valuation of contingent consideration (100) 2,400
Unrealized (gain) loss on ClearPoint Equity Investments (9) 39
Unrealized gain on ClearPoint convertible debt security (166) (59)
Unrealized gain on marketable securities - equity investments (710) (2,166)
Disposal of asset 544  
Deferred income taxes (1) (4)
Amortization of discounts on investments, net (3,697) (85)
Amortization of debt issuance costs 296 438
Share-based compensation expense 18,378 28,815
Unrealized foreign currency transaction losses (gains), net 269 (10,057)
Changes in operating assets and liabilities:    
Inventory, net 120 (4,612)
Prepaid expenses and other current assets 93,904 57,611
Trade and royalty receivables, net (39,500) (43,426)
Deposits and other assets 11,192 743
Accounts payable and accrued expenses (5,389) 33,524
Other liabilities 5,984 (3,988)
Deferred revenue (801) (1,137)
Net cash provided by (used in) operating activities 70,761 (29,491)
Cash flows from investing activities    
Purchases of fixed assets (9,588) (10,270)
Purchases of marketable securities - available for sale (104,373)  
Purchases of marketable securities - equity investments (9,065)  
Sale and redemption of marketable securities- available for sale 61,650 12,500
Sale and redemption of marketable securities - equity investments 1,207 2,196
Acquisition of product rights and licenses (54,763) (33,397)
Net cash used in investing activities (114,932) (28,971)
Cash flows from financing activities    
Proceeds from exercise of options 2,030 5,655
Debt issuance costs related to secured term loan   (182)
Payment of finance lease principal (1,490) (1,379)
Net cash provided by financing activities 540 4,094
Effect of exchange rate changes on cash (2,030) (7,963)
Net decrease in cash and cash equivalents (45,661) (62,331)
Cash and cash equivalents, and restricted cash beginning of period 610,284 295,925
Cash and cash equivalents, and restricted cash end of period 564,623 233,594
Supplemental disclosure of cash information    
Cash paid for interest 3,666 12,956
Cash paid for income taxes 2,042 2,215
Supplemental disclosure of non-cash investing and financing activity    
Unrealized (loss) gain on marketable securities, net of tax (444) 54
Right-of-use assets obtained in exchange for operating lease obligations 1,723  
Acquisition of product rights and licenses 2,296 19,406
Milestone payable $ 2,500 32,500
Debt issuance costs related to senior secured term loan   45
Capital expenditures unpaid at the end of period   $ 28