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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2024 | Jun. 30, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023
Cash flows from operating activities |  |  |  |  |
Net Income (Loss) | $ (99,179) | $ (198,883) | $ (190,755) | $ (337,842) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation and amortization |  |  | 62,413 | 93,830 |
Non-cash operating lease expense |  |  | 4,472 | 5,674 |
Non-cash royalty revenue related to sale of future royalties |  |  | (73,349) | (29,059) |
Non-cash interest expense on liability related to sale of future royalties |  |  | 102,340 | 37,753 |
Intangible asset impairment |  | 217,800 |  | 217,800 |
Change in valuation of contingent consideration |  |  | 5,000 | (126,500) |
Tangible asset impairment | 200 |  | 168 |  |
Loss on sale of fixed assets |  |  | 3,772 |  |
Gain on lease terminations | (2,200) |  | (2,179) |  |
Unrealized loss on ClearPoint Equity Investments |  |  | 1,252 | 1,112 |
Unrealized loss on ClearPoint convertible debt security |  |  | 1,931 | 1,539 |
Unrealized gain on marketable securities - equity investments |  |  | (1,111) | (4,364) |
Realized loss for the sale of Clearpoint Equity Investment |  |  |  | 782 |
Non-cash stock consideration, milestone payment |  |  |  | 29,570 |
Disposal of asset |  |  |  | 133 |
Deferred income taxes |  |  | 1 | (50,907) | $ (46,900)
Amortization of discounts on investments, net |  |  | (6,993) | (88) |
Amortization of debt issuance costs |  |  | 591 | 1,001 |
Share-based compensation expense |  |  | 37,621 | 58,186 |
Unrealized foreign currency transaction gains, net |  |  | (198) | (13,332) |
Changes in operating assets and liabilities: |  |  |  |  |
Inventory, net |  |  | (1,816) | (9,795) |
Prepaid expenses and other current assets |  |  | 99,791 | 63,951 |
Trade and royalty receivables, net |  |  | (31,310) | (18,022) |
Deposits and other assets |  |  | 10,062 | 6,936 |
Accounts payable and accrued expenses |  |  | (18,702) | 32,437 |
Other liabilities |  |  | (2,892) | (3,055) |
Deferred revenue |  |  | (801) | (1,351) |
Net cash provided by (used in) operating activities |  |  | (692) | (43,611) |
Cash flows from investing activities |  |  |  |  |
Purchases of fixed assets |  |  | (2,213) | (16,515) |
Proceeds from sale of fixed assets |  |  | 28,038 |  |
Purchases of marketable securities - available for sale |  |  | (291,734) |  |
Purchases of marketable securities - equity investments |  |  | (17,406) | (18,159) |
Sale and redemption of marketable securities- available for sale |  |  | 136,650 | 21,544 |
Sale and redemption of marketable securities - equity investments |  |  | 20,573 | 4,249 |
Sale and redemption of ClearPoint Equity Investments |  |  |  | 2,594 |
Acquisition of product rights and licenses |  |  | (54,763) | (46,436) |
Net cash used in investing activities |  |  | (180,855) | (52,723) |
Cash flows from financing activities |  |  |  |  |
Proceeds from exercise of options |  |  | 4,747 | 20,325 |
Proceeds from employee stock purchase plan |  |  | 1,973 | 3,805 |
Proceeds from sales of future royalties |  |  | 241,792 |  |
Debt issuance costs related to secured term loan |  |  |  | (197) |
Payment of finance lease principal |  |  | (1,490) | (1,379) |
Net cash provided by financing activities |  |  | 247,022 | 22,554 |
Effect of exchange rate changes on cash |  |  | (7,217) | 2,351 |
Net increase (decrease) in cash and cash equivalents |  |  | 58,258 | (71,429) |
Cash and cash equivalents, and restricted cash beginning of period |  |  | 610,284 | 295,925 | 295,925
Cash and cash equivalents, and restricted cash end of period | 668,542 | 224,496 | 668,542 | 224,496 | $ 610,284
Supplemental disclosure of cash information |  |  |  |  |
Cash paid for interest |  |  | 3,666 | 22,310 |
Cash paid for income taxes |  |  | 6,117 | 9,196 |
Supplemental disclosure of non-cash investing and financing activity |  |  |  |  |
Unrealized (loss) gain on marketable securities, net of tax | (112) | 397 | (556) | 451 |
Right-of-use assets obtained in exchange for operating lease obligations |  |  | 1,723 |  |
Acquisition of product rights and licenses |  |  | 3,105 | 36,879 |
Fixed asset additions through tenant improvement allowance |  |  | 16,739 |  |
Milestone payable | $ 37,500 | $ 2,500 | $ 37,500 | 2,500 |
Debt issuance costs related to senior secured term loan |  |  |  | 38 |
Capital expenditures unpaid at the end of period |  |  |  | $ 36 |

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- Definition Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481830/320-10-45-11 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-13 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-11 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-13 + Details
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- Definition Amount of cash outflow for purchase of marketable security. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 320 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 11 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481830/320-10-45-11 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-13 + Details
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