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Accounts payable and accrued expenses - Components (Details) - USD ($) $ in Thousands | Jun. 30, 2024 | Dec. 31, 2023 | Jun. 30, 2023
--- | --- | --- | ---
Payables and Accruals [Abstract] |  |  |
Employee compensation, benefits, and related accruals | $ 36,711 | $ 62,643 |
Income tax payable | 3,699 |  |
Consulting and contracted research | 21,814 | 27,500 |
Professional fees | 2,429 | 2,246 |
Sales allowance | 66,780 | 77,176 |
Sales rebates | 118,652 | 131,334 |
Royalties | 14,942 | 74,111 |
Accounts payable | 24,279 | 6,045 |
Milestone Payable | 37,500 |  | $ 2,500
Other | 11,994 | 10,928 |
Accounts payable and accrued expenses | $ 338,800 | $ 391,983 |

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