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Intangible assets and goodwill - Definite-lived Intangibles (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2024 | Jun. 30, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023
Definite-lived intangible assets |  |  |  |  |
Milestone Payable | $ 37,500 | $ 2,500 | $ 37,500 | $ 2,500 |
Accrued royalties | 14,942 |  | 14,942 |  | $ 74,111
Definite-lived intangibles |  |  |  |  |
Amortization | (2,865) | (47,397) | (54,395) | (86,812) |
Finite-Lived Intangible Assets, Net | $ 94,113 |  | $ 94,113 |  |
Weighted Average |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |
Remaining amortization period | 9 years |  | 9 years |  |
Akcea | Waylivra |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |
Royalty payments |  |  | $ 2,100 |  |
Akcea | Waylivra | Accounts payable and accrued expenses |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |
Accrued royalties | $ 500 |  | 500 |  |
Akcea | Tegsedi |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |
Royalty payments |  |  | 3,100 |  |
Akcea | Tegsedi | Accounts payable and accrued expenses |  |  |  |  |
Definite-lived intangible assets |  |  |  |  |
Accrued royalties | 2,700 |  | 2,700 |  |
Definite-lived intangible assets |  |  |  |  |
Definite-lived intangibles |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  | 640,507 |  |
Additions |  |  | 5,279 |  |
Foreign Currency Translation |  |  | (746) |  |
Ending balance - Definite-lived assets, Gross | 645,040 |  | 645,040 |  |
Beginning balance - Accumulated amortization |  |  | (496,776) |  |
Amortization | (2,900) | $ 47,400 | (54,395) | $ 86,800 |
Foreign Currency Translation - Accumulated amortization |  |  | 244 |  |
Ending balance - Accumulated amortization | (550,927) |  | (550,927) |  |
Finite-Lived Intangible Assets, Net | 94,113 |  | 94,113 |  |
Definite-lived intangible assets | Emflaza |  |  |  |  |
Definite-lived intangibles |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  | 527,417 |  |
Ending balance - Definite-lived assets, Gross | 527,417 |  | 527,417 |  |
Beginning balance - Accumulated amortization |  |  | (478,618) |  |
Amortization |  |  | (48,799) |  |
Ending balance - Accumulated amortization | (527,417) |  | (527,417) |  |
Definite-lived intangible assets | Waylivra |  |  |  |  |
Definite-lived intangibles |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  | 10,218 |  |
Additions |  |  | 2,130 |  |
Foreign Currency Translation |  |  | (324) |  |
Ending balance - Definite-lived assets, Gross | 12,024 |  | 12,024 |  |
Beginning balance - Accumulated amortization |  |  | (3,965) |  |
Amortization |  |  | (756) |  |
Foreign Currency Translation - Accumulated amortization |  |  | 131 |  |
Ending balance - Accumulated amortization | (4,590) |  | (4,590) |  |
Definite-lived intangible assets | Tegsedi |  |  |  |  |
Definite-lived intangibles |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  | 13,322 |  |
Additions |  |  | 3,149 |  |
Foreign Currency Translation |  |  | (422) |  |
Ending balance - Definite-lived assets, Gross | 16,049 |  | 16,049 |  |
Beginning balance - Accumulated amortization |  |  | (3,311) |  |
Amortization |  |  | (1,108) |  |
Foreign Currency Translation - Accumulated amortization |  |  | 113 |  |
Ending balance - Accumulated amortization | (4,306) |  | (4,306) |  |
Definite-lived intangible assets | Upstaza |  |  |  |  |
Definite-lived intangibles |  |  |  |  |
Beginning balance - Definite-lived assets, Gross |  |  | 89,550 |  |
Ending balance - Definite-lived assets, Gross | 89,550 |  | 89,550 |  |
Beginning balance - Accumulated amortization |  |  | (10,882) |  |
Amortization |  |  | (3,732) |  |
Ending balance - Accumulated amortization | $ (14,614) |  | $ (14,614) |  |

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