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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis $ in Thousands | Jun. 30, 2024 USD ($) | May 31, 2024 USD ($) | Dec. 31, 2023 USD ($) | Jun. 30, 2023 USD ($) | Dec. 31, 2022 USD ($)
--- | --- | --- | --- | --- | ---
Significant unobservable inputs (Level 3) | Upstaza |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Fair value | $ 21,300 |  |  |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Potential milestones | 0 |  | $ 0 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Potential milestones | $ 11,000 |  | $ 31,000 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.95 |  |  |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement |  |  | 0.85 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement |  |  | 0.92 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Minimum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.060 |  | 0.058 |  |
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Maximum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.062 |  | 0.061 |  |
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.95 |  |  |  |
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Weighted Average |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.061 |  |  |  |
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Fair value | $ 9,800 |  | $ 26,600 | $ 26,400 | $ 82,500
Regulatory Milestones | Accounts payable and accrued expenses |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Milestone payments triggered |  | $ 20,000 |  |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Potential milestones | 0 |  | 0 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Potential milestones | $ 50,000 |  | $ 50,000 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.95 |  | 0.85 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 1 |  | 1 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0 |  | 0 |  |
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Discount Rate |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.12 |  | 0.11 |  |
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.98 |  |  |  |
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Discount Rate | Weighted Average |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Rights Exchange Settlement measurement | 0.120 |  |  |  |
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments |  |  |  |  |
Fair Value Valuation Inputs |  |  |  |  |
Fair value | $ 11,500 |  | $ 9,700 | $ 11,100 | $ 81,500

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