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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Dec. 22, 2017
Jun. 30, 2022
USD ($)
Jun. 30, 2024
USD ($)
country
Jun. 30, 2023
USD ($)
country
Jun. 30, 2024
USD ($)
country
Jun. 30, 2023
USD ($)
country
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2019
USD ($)
Jul. 31, 2025
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Allowance for credit loss     $ 0 $ 0 $ 0 $ 0          
Increase in allowance for credit losses     0 0 0 0          
Allowance for doubtful accounts receivable     600   600     $ 1,200      
Revenue     186,704 $ 213,808 396,822 434,190          
Income taxes                      
Federal income tax statutory rate 21.00%                    
Deferred tax benefit         (1) $ 50,907   $ 46,900      
Forecast                      
Income taxes                      
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174.             $ 93,000        
Agilis                      
Income taxes                      
Deferred tax liability                     $ 122,000
Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Bank guarantee denominated in foreign currency     600   600            
Hopewell Campus                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit     $ 5,000   $ 5,000         $ 3,000  
Period after which letter of credit may be reduced if lease is not in default                 5 years    
Hopewell Campus | Minimum                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Term for letter of credit (in years)                 5 years    
Hopewell Campus | Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit                 $ 7,500    
Hopewell Campus | Fifth Anniversary                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit                 $ 3,800    
Warren Premises                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Period after which letter of credit may be reduced if lease is not in default   5 years                  
Warren Premises | Deposits and other assets                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit   $ 8,100                  
Warren Premises | Fifth Anniversary                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Letters of credit   $ 4,100                  
Net product revenue | Geographic concentration risk                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Number of countries exceeding 10% of net product sales | country     2 3 3 3          
Percentage of net product sales threshold     10.00% 10.00% 10.00% 10.00%          
Net product revenue | Geographic concentration risk | Non-US                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     $ 85,900 $ 108,900 $ 206,000 $ 241,800          
Net product revenue | Geographic concentration risk | Russia                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue       19,100 54,800 63,700          
Net product revenue | Geographic concentration risk | Brazil                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     30,400 23,100 39,100 48,900          
Net product revenue | Geographic concentration risk | United States                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     $ 47,300 $ 65,700 $ 104,800 $ 120,300          
Net product revenue | Customer concentration risk                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Percentage of net product sales threshold     10.00% 10.00% 10.00% 10.00%          
Product                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     $ 133,220 $ 174,592 $ 310,824 $ 362,149          
Emflaza | Net product revenue | Geographic concentration risk | United States                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     47,300 65,700 104,800 120,300          
Translarna | Net product revenue | Geographic concentration risk | Non-US                      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                      
Revenue     $ 70,400 $ 96,500 $ 173,900 $ 211,600