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Summary of significant accounting policies - Liability for Sale of Future Royalties (Details)
$ in Thousands
 1 Months Ended 6 Months Ended
Jun. 30, 2024
USD ($)
tranche
Jun. 30, 2024
USD ($)
Assigned royalty payments    
Cash received from Royalty Pharma   $ 241,792
Effective interest rate of the liability component 9.90% 9.90%
A&R Royalty Purchase Agreement    
Assigned royalty payments    
Cash received from Royalty Pharma $ 241,800  
Assigned royalty payment, retained percentage 9.51% 9.51%
Royalty purchase agreement termination period once there are no further royalty payment obligations 60 days  
Effective interest rate of the liability component 9.90% 9.90%
Aggregate percentage of royalty rights sold   90.49%
Percentage of maximum royalty payable thereafter assigned royalty rights   83.33%
Liability recognized for sale of future royalties. $ 241,800 $ 241,800
Adjusted percentage of retained royalty rights after the 2020 Assigned Royalty Cap is met 16.67%  
A&R Royalty Purchase Agreement | Maximum    
Assigned royalty payments    
Number of tranches to sell retained royalty | tranche 3  
A&R Royalty Purchase Agreement | Royalty Pharma    
Assigned royalty payments    
Assigned Royalty Cap per terms of the royalty purchase agreement $ 1,300,000 1,300,000
Aggregate upfront cash consideration received for sale of future royalties   1,900,000
A&R Royalty Purchase Agreement Tranche One    
Assigned royalty payments    
Aggregate percentage of royalty rights sold 3.81%  
Contract price for sale of specified percentage of future royalties $ 100,000 100,000
Adjusted percentage of retained royalty rights sold after the 2020 Assigned Royalty Cap is met 6.67%  
A&R Royalty Purchase Agreement Tranche Two    
Assigned royalty payments    
Aggregate percentage of royalty rights sold 3.81%  
Contract price for sale of specified percentage of future royalties $ 100,000 100,000
Adjusted percentage of retained royalty rights sold after the 2020 Assigned Royalty Cap is met 6.67%  
A&R Royalty Purchase Agreement Tranche Three    
Assigned royalty payments    
Aggregate percentage of royalty rights sold 1.90%  
Contract price for sale of specified percentage of future royalties $ 50,000 $ 50,000
Adjusted percentage of retained royalty rights sold after the 2020 Assigned Royalty Cap is met 3.33%