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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis $ in Thousands	Jun. 30, 2024 USD ($)	May 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Jun. 30, 2023 USD ($)	Dec. 31, 2022 USD ($)
Significant unobservable inputs (Level 3) | Upstaza
Fair Value Valuation Inputs
Fair value	$ 21,300
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	0		$ 0
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 11,000		$ 31,000
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.95
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.85
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement			0.92
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.060		0.058
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.062		0.061
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.95
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.061
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value	$ 9,800		$ 26,600	$ 26,400	$ 82,500
Regulatory Milestones | Accounts payable and accrued expenses
Fair Value Valuation Inputs
Milestone payments triggered		$ 20,000
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0		0
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 50,000		$ 50,000
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.95		0.85
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	1		1
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0		0
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.12		0.11
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.98
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.120
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value	$ 11,500		$ 9,700	$ 11,100	$ 81,500

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