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Revenue recognition - Collaboration and Royalty Revenue (Details) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024 USD ($)	Jun. 30, 2023 USD ($)	Jun. 30, 2024 USD ($) product	Jun. 30, 2023 USD ($)	Nov. 30, 2011 USD ($)
Revenue recognition
Number of approved products | product			2
Revenue	$ 186,704	$ 213,808	$ 396,822	$ 434,190
Collaboration revenue
Revenue recognition
Revenue				6
Royalty revenue
Revenue recognition
Revenue	53,183	36,853	$ 84,337	67,684
SMA License Agreement
Revenue recognition
Number of approved products | product			1
SMA License Agreement | Royalty revenue
Revenue recognition
Revenue	53,200	$ 36,900	$ 84,300	$ 67,700
Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	0		0
Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved	$ 150,000		$ 150,000
Maximum | Research And Development Event Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved					$ 135,000
Maximum | Sales Milestones | SMA License Agreement
Revenue recognition
Remaining potential milestones that can be achieved					$ 325,000

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