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Stock award plan - (Tables)

9 Months Ended

Sep. 30, 2024

Share-based Payment Arrangement [Abstract]

Summary of stock option activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​		​		​	​		Weighted-			​	​
​	​	​	​	Weighted-		​	average	​	​	Aggregate
​	​	​	​	average		​	remaining	​	​	intrinsic
​	​	Number of	​	exercise		​	contractual	​	​	value(in
​	​	options	​	price		​	term	​	​	thousands)
​	​	​	​	​	​	​	​		​	​	​
Outstanding at December 31, 2023		9,600,399	​	$	43.59				​	​
Granted		934,735	​	​	26.13				​	​
Exercised		(211,693)	​	​	22.41				​	​
Forfeited/Cancelled		(1,149,981)	​	​	45.86				​	​
Outstanding at September 30, 2024		9,173,460	​	$	42.01		5.64	years	​	$	30,906
Vested or Expected to vest at September 30, 2024		1,746,884	​	$	35.85		8.45	years	​	$	9,289
Exercisable at September 30, 2024		7,254,847	​	$	43.74		4.89	years	​	$	20,420

​

Schedule of assumptions used to estimate fair values of grants made on the date of grant

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​	​	​	​
​		Nine months ended
​		September 30, 2024
Risk-free interest rate		3.51% - 4.66%
Expected volatility		53% - 54%
Expected term		5.5 years

Summary of information on the Company's restricted stock

​

​	​	​	​	​	​
​	​	Restricted Stock Units
​	​	​	​	Weighted
​	​	​	​	Average
​	​	​	​	Grant
​	​	Number of	​	Date
​		Shares		Fair Value
Unvested at December 31, 2023	​	2,866,270	​	$	41.82
Granted		1,850,265	​	​	25.87
Vested		(924,417)	​	​	44.08
Forfeited		(195,789)	​	​	37.28
Unvested at September 30, 2024		3,596,329	​	$	33.29

Schedule of share-based compensation expense recorded in the statement of operations

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Three Months Ended September 30,

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Nine Months Ended September 30,

​

​

2024

2023

2024

2023

​

Research and development

​

$

9,416

​

$

13,986

​

$

27,810

​

$

44,828

​

Selling, general and administrative

​

10,339

​

12,956

​

29,566

​

40,300

​

Total

​

$

19,755

​

$

26,942

​

$

57,376

​

$

85,128

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Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

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-Name Accounting Standards Codification
-Section 50
-Subparagraph (c)
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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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