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Consolidated Statements of Operations - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Sep. 30, 2024
Sep. 30, 2023
Revenues:        
Revenue $ 196,786,000 $ 196,576,000 $ 593,608,000 $ 630,766,000
Operating expenses:        
Cost of product sales, excluding amortization of acquired intangible assets 10,848,000 9,493,000 41,115,000 36,368,000
Amortization of acquired intangible assets 3,036,000 58,649,000 57,431,000 145,461,000
Research and development 161,412,000 164,212,000 409,710,000 545,210,000
Selling, general and administrative 73,456,000 80,886,000 216,228,000 256,249,000
Change in the fair value of contingent consideration 700,000 1,500,000 5,700,000 (125,000,000)
Intangible asset impairment       217,800,000
Tangible asset impairment and losses (gains) on transactions, net 1,844,000   3,605,000  
Total operating expenses 251,296,000 314,740,000 733,789,000 1,076,088,000
Loss from operations (54,510,000) (118,164,000) (140,181,000) (445,322,000)
Interest expense, net (41,609,000) (28,160,000) (125,933,000) (84,905,000)
Other expense, net (1,872,000) (20,266,000) (2,306,000) (8,832,000)
Loss before income tax (expense) benefit (97,991,000) (166,590,000) (268,420,000) (539,059,000)
Income tax (expense) benefit (8,663,000) 33,620,000 (28,989,000) 68,247,000
Net loss attributable to common stockholders $ (106,654,000) $ (132,970,000) $ (297,409,000) $ (470,812,000)
Weighted-average shares outstanding:        
Basic 76,925,523 75,377,997 76,716,340 74,618,611
Diluted 76,925,523 75,377,997 76,716,340 74,618,611
Net loss per share-basic and diluted (in dollars per share)        
Basic $ (1.39) $ (1.76) $ (3.88) $ (6.31)
Diluted $ (1.39) $ (1.76) $ (3.88) $ (6.31)
Net product revenue        
Revenues:        
Revenue $ 135,421,000 $ 144,038,000 $ 446,245,000 $ 506,187,000
Collaboration revenue        
Revenues:        
Revenue       6,000
Royalty revenue        
Revenues:        
Revenue 61,365,000 50,173,000 145,702,000 117,857,000
Manufacturing revenue        
Revenues:        
Revenue $ 0 $ 2,365,000 $ 1,661,000 $ 6,716,000