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Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2024	Sep. 30, 2023
Upstaza
Changes in the fair value of warrant liability and SARs liability
Ending Balance	$ 22,000
Development and Regulatory Milestones | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	26,600	$ 82,500
Additions	0	0
Change in fair value	3,300	(56,100)
Reclassification to accounts payable and accrued expenses	0
Rights Exchange settlement	(20,000)	0
Ending Balance	9,900	26,400
Net Sales Milestones and Royalties | Commitments
Changes in the fair value of warrant liability and SARs liability
Beginning Balance	9,700	81,500
Additions	0	0
Change in fair value	2,400	(68,900)
Reclassification to accounts payable and accrued expenses	0
Rights Exchange settlement	0	0
Ending Balance	$ 12,100	$ 12,600

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- Definition

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+ References

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- Definition

Amount of transfers of financial instrument classified as a liability out of level 3 of the fair value hierarchy.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-3

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
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- Definition

Amount of gain (loss) recognized in income from liability measured at fair value on recurring basis using unobservable input (level 3).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
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-URI https://asc.fasb.org/1943274/2147482106/820-10-50-3

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Amount of issuances of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482106/820-10-50-3

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Amount of settlements of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
-SubTopic 10
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Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 820
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-Section 50
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-URI https://asc.fasb.org/1943274/2147482106/820-10-50-3

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