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Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis $ in Thousands	1 Months Ended	3 Months Ended	9 Months Ended	12 Months Ended
	May 31, 2024 USD ($)	Sep. 30, 2024 USD ($)	Sep. 30, 2024 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2023 USD ($)	Sep. 30, 2023 USD ($)
Fair Value Valuation Inputs
Milestone obligation payments made				$ 50,000
Significant unobservable inputs (Level 3) | Upstaza
Fair Value Valuation Inputs
Fair value		$ 22,000	$ 22,000
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones		0	0		$ 0
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones		$ 11,000	$ 11,000		$ 31,000
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.95	0.95
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement					0.85
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement					0.92
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.054	0.054		0.058
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.055	0.055		0.061
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.95	0.95
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.055	0.055
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value		$ 9,900	$ 9,900	82,500	$ 26,600	$ 26,400
Regulatory Milestones
Fair Value Valuation Inputs
Milestone obligation payments made	$ 20,000	20,000	20,000
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones		0	0		0
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones		$ 50,000	$ 50,000		$ 50,000
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.95	0.95		0.85
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		1	1		1
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.13	0.13		0.11
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.98	0.98
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement		0.130	0.130
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value		$ 12,100	$ 12,100	$ 81,500	$ 9,700	$ 12,600

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