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Stock award plan - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jun. 08, 2022
Dec. 31, 2022
Jun. 30, 2021
Dec. 31, 2020
Sep. 30, 2024
Sep. 30, 2023
Sep. 30, 2024
Sep. 30, 2023
Apr. 30, 2022
May 31, 2021
Jan. 31, 2020
Stock option plan                      
Share-based compensation expense         $ 19,755 $ 26,942 $ 57,376 $ 85,128      
Unrecognized compensation cost         117,800   $ 117,800        
Weighted average remaining service period for recognition of unrecognized compensation cost             2 years 3 months 18 days        
Stock option                      
Stock option plan                      
Granted (in shares)             934,735        
Options forfeited (in shares)             1,149,981        
Expected dividend yield (as a percent)             0.00%        
Weighted average grant date fair value (in dollars per share)             $ 13.71        
Restricted stock units                      
Stock option plan                      
Granted (in shares)             1,850,265        
Employee Stock Purchase Plan                      
Stock option plan                      
Number of shares authorized (in shares)     2,000,000             1,000,000  
Award requisite service period     6 months                
Purchase price of common stock, percent     85.00%                
Employee stock purchase plan, voting percentage limit     5.00%                
Share-based compensation expense         $ 500   $ 1,700        
1998 Employee, Director, and Consultant Stock Option Plan, 2009 Equity and Long-term Incentive Plan, and 2013 Stock Incentive Plan | Common stock                      
Stock option plan                      
Number of shares available for issuance         0   0        
Amended 2013 LTIP                      
Stock option plan                      
Number of shares available for issuance         6,781,585   6,781,585        
Number of additional shares authorized (in shares) 8,475,000                    
Amended 2013 LTIP | Maximum                      
Stock option plan                      
Number of shares authorized (in shares) 16,724,212                    
2020 Inducement Stock Incentive Plan | Common stock                      
Stock option plan                      
Number of shares available for issuance         1,989,775   1,989,775        
Number of additional shares authorized (in shares)   1,700,000   1,000,000              
2020 Inducement Stock Incentive Plan | Common stock | Maximum                      
Stock option plan                      
Number of shares authorized (in shares)                 1,300,000   1,000,000
2020 Inducement Stock Incentive Plan | Stock option                      
Stock option plan                      
Granted (in shares)             934,735        
Stockholder's specified ownership percentage         10.00%   10.00%        
Inducement grants for non-statutory stock options (in shares)             27,490        
Vesting period             4 years        
2020 Inducement Stock Incentive Plan | Stock option | Minimum                      
Stock option plan                      
Stock options granted, exercise price as percentage of the fair market value of common stock at grant date         100.00%   100.00%        
2020 Inducement Stock Incentive Plan | Stock option | Maximum                      
Stock option plan                      
Stock options granted to stockholder with specified ownership percentage, exercise price as percentage of the fair market value of common stock at grant date         110.00%   110.00%        
Expiration period             10 years        
2020 Inducement Stock Incentive Plan | Restricted stock units                      
Stock option plan                      
Granted (in shares)             41,680