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Consolidated Statements of Operations - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Revenues:      
Revenue $ 806,780,000 $ 937,822,000 $ 698,801,000
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible assets 57,398,000 65,486,000 44,678,000
Amortization of acquired intangible assets 60,738,000 222,635,000 116,554,000
Research and development 534,480,000 666,563,000 651,496,000
Selling, general and administrative 300,911,000 332,540,000 325,998,000
Change in the fair value of contingent consideration (4,475,000) (127,700,000) (25,900,000)
Intangible asset impairment 159,548,000 217,800,000 33,384,000
Tangible asset impairment and losses (gains) on transactions, net 750,000    
Total operating expenses 1,109,350,000 1,377,324,000 1,146,210,000
Loss from operations (302,570,000) (439,502,000) (447,409,000)
Interest expense, net (166,993,000) (129,180,000) (90,871,000)
Other income (expense), net 6,544,000 10,130,000 (49,207,000)
Gain on sale of priority review voucher 99,900,000    
Loss on extinguishment of debt   (137,558,000)  
Loss before income tax (expense) benefit (363,119,000) (696,110,000) (587,487,000)
Income tax (expense) benefit (176,000) 69,506,000 28,470,000
Net loss attributable to common stockholders $ (363,295,000) $ (626,604,000) $ (559,017,000)
Weighted-average shares outstanding:      
Basic 76,845,055 74,838,392 71,728,634
Diluted 76,845,055 74,838,392 71,728,634
Net loss per share-basic and diluted (in dollars per share)      
Basic $ (4.73) $ (8.37) $ (7.79)
Diluted $ (4.73) $ (8.37) $ (7.79)
Net product revenue      
Revenues:      
Revenue $ 600,951,000 $ 661,249,000 $ 535,228,000
Collaboration revenue      
Revenues:      
Revenue 304,000 100,030,000 50,052,000
Royalty revenue      
Revenues:      
Revenue 203,864,000 168,856,000 113,521,000
Manufacturing revenue      
Revenues:      
Revenue $ 1,661,000 $ 7,687,000 $ 0